gene

TBAK1

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about TBAK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

TBK1 Gene

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🧬 Gene Info

Gene Symbol	TBAK1
Full Name	TANK-Binding Kinase 1
Chromosome	12q14.1
Protein Type	Serine/Threonine Kinase
Function	TBK1 is a serine/threonine kinase with critical roles in multiple cellular pathways[@cirulli2015]:
Primary Expression	neurons, astrocytes, and microglia - Spinal Cord: High expression in motor neu
Amino Acids	729 aa
Exons	21
UniProt ID	Q9UHD2
NCBI Gene ID	29142
Ensembl ID	ENSG00000183735
OMIM	604834
GeneCards	TBAK1
Human Protein Atlas	TBAK1
Kinase Domain (KD)	Residues 1-307, catalyzes phosphorylation
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TBAK1 — AlphaFold Q9UHD2 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

TBK1 Gene

gene · 1021 words

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Pathway Diagram

graph TD
    TBAK1["TBAK1"]
    neurodegeneration["neurodegeneration"]
    TBAK1 -->|"implicated_in"| neurodegeneration
    style TBAK1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning TBAK1 in their description or question text

No additional research found