gene

ST6GALNAC5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ST6GALNAC5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

5Connections

0Hypotheses

0Analyses

1Outgoing

4Incoming

0Experiments

0Debates

Summary

ST6GALNAC5 - astrocyte sialyltransferase that when knocked down improves spatial memory in AD mice. Sialylation of glycoproteins in astrocytes, neural cell adhesion, therapeutic potential in Alzheimer's disease

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🧬 Gene Info

Gene Symbol	ST6GALNAC5
Full Name	ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
Chromosome	1p31.3
Protein Type	Sialyltransferase
Function	Sialylation of glycoproteins, neural cell adhesion
Primary Expression	Astrocytes, brain
UniProt ID	Q9H0X9
NCBI Gene ID	256297
Ensembl ID	ENSG00000160584
GeneCards	ST6GALNAC5
Human Protein Atlas	ST6GALNAC5
Associated Diseases	Alzheimer's disease
KG Connections	5 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: ST6GALNAC5 — AlphaFold Q9H0X9 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

ST6GALNAC5 Gene

gene · 1015 words

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ST6GALNAC5 Gene

gene · 1092 words

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Pathway Diagram

flowchart TD
    N0["ST6GALNAC5"]
    N1["BLOOD-BRAIN BARRIER"]
    N0 -->|"mediates"| N1
    N2["neurodegeneration"]
    N0 -->|"implicated in"| N2

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0

Outgoing (1)

Target	Relation	Type	Str
TREM2	debate_co_mention	gene	0.45

Incoming (4)

Source	Relation	Type	Str
APOE	debate_co_mention	gene	0.45
autophagy	debate_co_mention	pathway	0.45
neuroinflammation	debate_co_mention	process	0.45
PARP1	debate_co_mention	gene	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ST6GALNAC5 in their description or question text

No additional research found