Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Ganglioside Biosynthesis: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
The stepwise enzymatic synthesis of gangliosides — sialic acid-containing glycosphingolipids highly enriched in neuronal membranes. Key enzymes include B4GALNT1 (GM2/GM3 synthase), ST3GAL5 (GM3 synthase), and B3GALT4 (GM1 synthase). Gangliosides GM1, GD1a, GD1b, and GT1b are crucial for synaptic transmission, neurotrophin signaling, and axon stability. Aberrant ganglioside metabolism is linked to gangliosidoses and Alzheimer's disease.
Ontology: GO:0001573 · MESH:D005735
No AI portrait yet
| Name | ganglioside_biosynthesis |
| Key Genes/Proteins | ST3GAL2 |
| Target | Relation | Type | Str |
|---|---|---|---|
| synaptic_membrane_organization | regulates | cell_type | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ST3GAL2 | modifies | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 13 hypotheses Top: 0.852
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 6 · Score: 0.95 · 2026-04-27
closed · Rounds: 4 · Score: 0.50 · 2026-04-27
closed · Rounds: 4 · Score: 0.40 · 2026-04-27
closed · Rounds: 4 · Score: 0.40 · 2026-04-27
closed · Rounds: 5 · Score: 0.93 · 2026-04-11
Hypotheses and analyses mentioning Ganglioside Biosynthesis in their description or question text
No additional research found