Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about excitatory_neuron: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer's disease | implicated_in | disease | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Excitatory Neuron Vulnerability via SLC17A7 Downregulation | 0.675 | Alzheimer's Disease | SEA-AD Gene Expression Profiling — Allen |
| Excitatory Neuron Synaptic Dysfunction and Mitochondrial Str | 0.660 | neurodegeneration | Cell type vulnerability debate in Alzhei |
| Layer V excitatory neurons show selectively enhanced vulnera | 0.632 | Alzheimer's disease | SEA-AD Single-Cell Analysis: Cell-Type V |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-11 | 0 hypotheses
neurodegeneration | 2026-04-11 | 0 hypotheses
neurodegeneration | 2026-04-10 | 0 hypotheses
neurodegeneration | 2026-04-10 | 0 hypotheses
neurodegeneration | 2026-04-10 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| iPSC-derived astrocyte-neuron co-culture mitochondrial transfer in PD | exploratory | Parkinson's disease | 0.900 | 0.00 | iPSC-derived dopaminergic neur | proposed | N/A |
| Autophagy receptor identification for stress granule elimination | exploratory | neurodegenerative diseases | 0.900 | 0.00 | cultured cells under arsenite | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Social Processing in the Amygdala: Single-Nucleus RNA-Sequencing Reveals Distinc [PMID:41727617] | Dwortz MF, Hofmann HA, Curley JP | Res Sq | 2026 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Sevoflurane aggravates hypoxic-ischemic encephalopathy in preterm neonates via V [PMID:40602692] | Qin M, Shi D, Song X, Zhang R, Feng Z, L | Brain research bulletin | 2025 | 0 |
| Audiogenic kindling activates glutamatergic system in the hippocampus of rats wi [PMID:38325559] | Aleksandrova EP, Ivlev AP, Kulikov AA, N | Brain research | 2024 | 0 |
| P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting [PMID:38513667] | Zhang D, Zhang W, Ming C, Gao X, Yuan H, | Neuron | 2024 | 0 |
| Alzheimer's Disease-associated Region-specific Decrease of Vesicular Glutamate T [PMID:38552733] | Wood OWG, Walby J, Yeung JH, Ke S, Palpa | Neuroscience | 2024 | 0 |
| Single-cell atlas reveals correlates of high cognitive function, dementia, and r [PMID:37774677] | Mathys H, Peng Z, Boix CA, Victor MB, Le | Cell | 2023 | 0 |
| Neurovascular dysfunction in GRN-associated frontotemporal dementia identified b [PMID:35879464] | Gerrits E, Giannini LAA, Brouwer N, Melh | Nature neuroscience | 2022 | 0 |
| Deciphering molecular interactions by proximity labeling. [PMID:33432242] | Qin W, Cho KF, Cavanagh PE, Ting AY | Nature methods | 2021 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| Tau protein aggregation is associated with cellular senescence in the brain. [PMID:30126037] | ["Musi Nicolas", "Valentine Joseph M", " | Aging cell | 2018 | 0 |
| Multiple Sclerosis Pathology. [PMID:29358320] | Lassmann H | Cold Spring Harbor perspective | 2018 | 0 |
| Tau protein aggregation is associated with cellular senescence in the brain. [PMID:30126037] | ["Musi Nicolas", "Valentine Joseph M", " | Aging cell | 2018 | 0 |
| Bolstering human rabies surveillance in Africa is crucial to eliminating canine- [PMID:30188896] | Anaïs Broban; Mathurin C Tejiokem; Issak | PLoS neglected tropical diseas | 2018 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.12 · 2026-04-27
closed · Rounds: 4 · Score: 0.42 · 2026-04-27
closed · Rounds: 4 · Score: 0.48 · 2026-04-27
closed · Rounds: 4 · Score: 0.47 · 2026-04-27
closed · Rounds: 4 · Score: 0.52 · 2026-04-27
closed · Rounds: 4 · Score: 0.72 · 2026-04-27
closed · Rounds: 0 · Score: 0.66 · 2026-04-21
closed · Rounds: 0 · Score: 0.64 · 2026-04-21
closed · Rounds: 4 · Score: 0.30 · 2026-04-21
closed · Rounds: 4 · Score: 0.30 · 2026-04-21
Hypotheses and analyses mentioning excitatory_neuron in their description or question text
No additional research found