Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about early MCI: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| gamma collapse | biomarker_for | phenotype | 0.70 |
| 40Hz gamma entrainment | therapeutic_target_for | process | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Closed-loop transcranial focused ultrasound with 40Hz gamma | 0.573 | Alzheimer's disease | Circuit-level neural dynamics in neurode |
Scientific analyses that reference this entity
neuroscience | 2026-04-03 | 73 hypotheses Top: 0.968
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Epigenetic clocks association with brain aging patterns in older women | exploratory | cognitive impairment and demen | 0.900 | 0.00 | human patients | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| A therapeutic small molecule enhances γ-oscillations and improves cognitio [PMID:39106304] | Unknown | Proceedings of the National Ac | 2024 | 0 |
| Parvalbumin Interneuron Dysfunction in Neurological Disorders: Focus on Epilepsy [PMID:38791587] | ["Leitch B"] | International journal of molec | 2024 | 0 |
| Transcranial alternating current stimulation (tACS) at gamma frequency: an up-an [PMID:38926897] | De Paolis ML, Paoletti I, Zaccone C | Transl Neurodegener | 2024 | 0 |
| Gamma frequency entrainment attenuates amyloid load and modifies microglia. [PMID:27929004] | ["Iaccarino H", "Singer A", "Martorell A | Nature | 2016 | 0 |
| Inhibitory interneuron deficit links altered network activity and cognitive dysf [PMID:22541439] | Verret L, Mann EO, Hang GB, Barth AM, Co | Cell | 2012 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 6 · Score: 0.95 · 2026-04-27
closed · Rounds: 6 · Score: 0.95 · 2026-04-27
closed · Rounds: 4 · Score: 0.65 · 2026-04-27
closed · Rounds: 4 · Score: 0.71 · 2026-04-27
closed · Rounds: 4 · Score: 0.87 · 2026-04-27
closed · Rounds: 4 · Score: 0.48 · 2026-04-27
closed · Rounds: 4 · Score: 0.54 · 2026-04-27
closed · Rounds: 4 · Score: 0.19 · 2026-04-27
closed · Rounds: 4 · Score: 0.40 · 2026-04-27
closed · Rounds: 4 · Score: 0.50 · 2026-04-27
Hypotheses and analyses mentioning early MCI in their description or question text
No additional research found