Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CYTOSOLIC CALCIUM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | CYTOSOLIC CALCIUM |
graph TD
CYTOSOLIC_CALCIUM[CYTOSOLIC CALCIUM]
CYTOSOLIC_CALCIUM -->|activates| CAMK2[CAMK2]
CYTOSOLIC_CALCIUM -->|regulates| Hepatic_Mitochondrial_Oxidatio[Hepatic Mitochondrial Oxidation]
CYTOSOLIC_CALCIUM -->|activates| CAMKII[CAMKII]
CYTOSOLIC_CALCIUM -->|activates| CAMK2A[CAMK2A]
CYTOSOLIC_CALCIUM -->|regulates| Hepatic_Fatty_Acid_Oxidation[Hepatic Fatty Acid Oxidation]
CYTOSOLIC_CALCIUM -->|modulates| Gluconeogenesis[Gluconeogenesis]
CYTOSOLIC_CALCIUM -->|regulates| intrahepatic_lipolysis[intrahepatic lipolysis]
MCU[MCU] -->|regulates| CYTOSOLIC_CALCIUM
MCU_Deletion[MCU Deletion] -->|upregulates| CYTOSOLIC_CALCIUM
mitochondrial_depolarization[mitochondrial depolarization] -->|causes| CYTOSOLIC_CALCIUM| Target | Relation | Type | Str |
|---|---|---|---|
| CAMK2 | activates | protein | 0.95 |
| Hepatic Mitochondrial Oxidation | regulates | process | 0.95 |
| CAMKII | activates | protein | 0.95 |
| CAMKII | activates | entity | 0.95 |
| Hepatic Fatty Acid Oxidation | regulates | process | 0.90 |
| CAMK2A | activates | protein | 0.90 |
| Hepatic Mitochondrial Oxidation | modulates | process | 0.85 |
| Gluconeogenesis | modulates | process | 0.85 |
| Gluconeogenesis | regulates | process | 0.80 |
| intrahepatic lipolysis | regulates | process | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MCU | regulates | entity | 0.95 |
| MCU Deletion | upregulates | process | 0.90 |
| MCU | upregulates | gene | 0.90 |
| mitochondrial depolarization | causes | process | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning CYTOSOLIC CALCIUM in their description or question text
No additional research found