Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about cryptic_exon_silencing: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| ALS | dysregulated_in | disease | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TDP-43 | regulates | protein | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Cryptic Exon Silencing Restoration | 0.531 | neurodegeneration | RNA binding protein dysregulation across |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.720
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| TDP-43 mutant mouse model cGAS/STING pathway analysis | validation | amyotrophic lateral sclerosis | 0.900 | 0.00 | TDP-43 mutant mice | proposed | N/A |
| TDP-43 mitochondrial invasion and DNA release via mPTP | exploratory | amyotrophic lateral sclerosis | 0.900 | 0.00 | cultured cells | proposed | N/A |
| TDP-43 mitochondrial invasion and mtDNA release in iPSC motor neurons | exploratory | Amyotrophic Lateral Sclerosis | 0.900 | 0.00 | iPSC-derived motor neurons | proposed | N/A |
| cGAS/STING pathway validation in TDP-43 mutant mice | validation | Amyotrophic Lateral Sclerosis | 0.850 | 0.00 | TDP-43 mutant mice | proposed | N/A |
| cGAMP biomarker analysis in ALS patient spinal cord samples | exploratory | Amyotrophic Lateral Sclerosis | 0.800 | 0.00 | Human ALS patient spinal cord | proposed | N/A |
| TDP-43 pathology prevalence and distribution in AD cases | exploratory | Alzheimer's disease | 0.800 | 0.00 | human postmortem brain tissue | proposed | N/A |
| Cognitive impact of TDP-43 pathology in AD patients | clinical | Alzheimer's disease | 0.700 | 0.00 | human patients | completed | N/A |
| s:** - Temporal analysis showing mitochondrial defects precede other p | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| Proposed experiment from debate on TDP-43 undergoes liquid-liquid phas | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| s:** - Single-cell RNA-seq to measure editing efficiency across differ | falsification | ALS | 0.400 | 0.50 | cell_line | proposed | $150,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Targets and Gene Therapy of ALS (Part 1). [PMID:40362304] | Shiryaeva O, Tolochko C, Alekseeva T, Dy | Int J Mol Sci | 2025 | 1 |
| The genetics of amyotrophic lateral sclerosis. [PMID:38967083] | Nijs M, Van Damme P | Curr Opin Neurol | 2024 | 1 |
| TDP-43 regulates LC3ylation in neural tissue through ATG4B cryptic splicing inhi [PMID:39305312] | Torres P, Rico-Rios S, Ceron-Codorniu M, | Acta Neuropathol | 2024 | 1 |
| TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A. [PMID:35197628] | Brown AL, Wilkins OG, Keuss MJ, Kargbo-H | Nature | 2022 | 1 |
| Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP- [PMID:28405022] | Becker LA, Huang B, Bieri G, Ma R, Knowl | Nature | 2017 | 1 |
| Selective Silencing of TDP-43 P. G376D Mutation Reverses Key Amyotrophic Lateral [PMID:41897327] | Romano R, Ruotolo G, Perrone F, Tomasell | Biomolecules | 2026 | 0 |
| ALS-related proteinopathies: From TDP-43 to mitochondrial proteinopathies. [PMID:41570741] | Genin EC, Paquis-Flucklinger V | Current opinion in neurobiolog | 2026 | 0 |
| Chemical and Molecular Strategies in Restoring Autophagic Flux in TDP-43 Protein [PMID:41900026] | Jamerlan A, Hulme J | Molecules (Basel, Switzerland) | 2026 | 0 |
| Axonal transport impairment as an upstream mechanism in amyotrophic lateral scle [PMID:41890591] | Gabbay U | Frontiers in neuroscience | 2026 | 0 |
| Role of Alpha-Synuclein in Frontotemporal Dementia: Narrative Review. [PMID:41827903] | Bougea A | Cells | 2026 | 0 |
| Versatile CRISPR-Cas Tools for Gene Regulation in Zebrafish via an Enhanced Q Bi [PMID:41671402] | ["Shi M", "Ge W", "Li C", "Liu B", "Deng | Advanced science (Weinheim, Ba | 2026 | 0 |
| Splicing the narrative: alternative TARDBP splicing and its relation to neurodeg [PMID:41837283] | Miller MR, Dykstra M, Barmada S | The Journal of clinical invest | 2026 | 0 |
| Multi-modal dissection of cell-type specific TDP-43 pathology in the motor corte [PMID:41803120] | Ruf WP, Kühlwein JK, Meier L, Brockmann | Nature communications | 2026 | 0 |
| A neurotoxic cryptic peptide arising from TDP-43-dependent cryptic splicing of P [PMID:41720774] | ["Yang M", "Wang Q", "Yan R", "Kang D", | Nature communications | 2026 | 0 |
| The Genetics of TDP-43 Type C Neurodegeneration: A Whole-Genome Sequencing Study [PMID:41883703] | Nassan M, Ayala I, Sloan J, Bonfitto A, | Neurology. Genetics | 2026 | 0 |
| Excitotoxicity in amyotrophic lateral sclerosis: a key pathogenic mechanism. [PMID:41890274] | Silva-Hucha S, Hernández RG, Baena-López | Brain communications | 2026 | 0 |
| PPAR-Delta Agonist Therapies Did Not Rescue Hallmark Disease Phenotypes in Two S [PMID:41751955] | ["Luong D", "Niu C", "Kim E", "Tanji N", | International journal of molec | 2026 | 0 |
| Transcriptomic signature of frontotemporal lobar degeneration with TDP-43 type C [PMID:41789476] | ["Rajicic A", "Mol M", "Melhem S", "Kisi | Brain : a journal of neurology | 2026 | 0 |
| Antisense oligonucleotide targeting TARDBP-EGFR splicing axis inhibits progressi [PMID:41540015] | Ni N, Wang M, Yuan Z, Zhang L, Cai J, Du | International journal of oral | 2026 | 0 |
| TDP-43 impairs glycolysis by sequestering hexokinase 1 in amyotrophic lateral sc [PMID:41838122] | Barone C, Wang R, Cooke S, Ng HP, Ferrei | Acta neuropathologica | 2026 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.72 · 2026-04-12
closed · Rounds: 4 · Score: 0.88 · 2026-04-06
Hypotheses and analyses mentioning cryptic_exon_silencing in their description or question text
No additional research found