Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about closed-loop tACS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| Gamma entrainment | modulates | process | 0.70 |
| stellate cell burst firing | inhibits | phenotype | 0.50 |
| PV interneurons | modulates | cell_type | 0.50 |
| inhibitory tone | modulates | process | 0.50 |
| theta-gamma coupling | modulates | mechanism | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Closed-loop tACS targeting EC-II parvalbumin interneurons to | 0.869 | Alzheimer's disease | Circuit-level neural dynamics in neurode |
| Closed-loop tACS targeting EC-II PV interneurons to suppress | 0.811 | Alzheimer's disease | Circuit-level neural dynamics in neurode |
| Closed-loop tACS targeting entorhinal cortex layer II SST in | 0.784 | Alzheimer's disease | Circuit-level neural dynamics in neurode |
| Closed-loop tACS targeting EC-II SST interneurons to block t | 0.752 | Alzheimer's disease | Circuit-level neural dynamics in neurode |
| Closed-loop tACS targeting EC-II PV interneurons to enhance | 0.596 | Alzheimer's disease | Circuit-level neural dynamics in neurode |
| Closed-loop tACS targeting EC-II somatostatin interneurons t | 0.564 | Alzheimer's disease | Circuit-level neural dynamics in neurode |
Scientific analyses that reference this entity
neuroscience | 2026-04-03 | 73 hypotheses Top: 0.968
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Home-Based Gamma Transcranial Alternating Current Stimulation in Patients With A [PMID:41359335] | ["Valentina Cantoni", "Elias Paolo Casul | JAMA network open | 2025 | 0 |
| Targeting Neural Oscillations for Cognitive Enhancement in Alzheimer’s Disease [PMID:40142358] | Federica Palacino, P. Manganotti, A. Ben | {'name': 'Medicina', 'volume': | 2025 | 0 |
| P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting [PMID:38513667] | Zhang D, Zhang W, Ming C, Gao X, Yuan H, | Neuron | 2024 | 0 |
| The necroptosis cell death pathway drives neurodegeneration in Alzheimer's disea [PMID:38852117] | Balusu S, De Strooper B | Acta neuropathologica | 2024 | 0 |
| Transcranial alternating current stimulation (tACS) at gamma frequency: an up-an [PMID:38926897] | De Paolis ML, Paoletti I, Zaccone C | Transl Neurodegener | 2024 | 0 |
| Parvalbumin neuroplasticity compensates for somatostatin impairment, maintaining [PMID:35501886] | Morrone CD, Lai AY, Bishay J, Hill ME, M | Translational neurodegeneratio | 2022 | 0 |
| Insulin Resistance and Diabetes Mellitus in Alzheimer's Disease. [PMID:34069890] | Burillo J, Marqués P, Jiménez B, Gonzále | Cells | 2021 | 0 |
| Impact of 40 Hz Transcranial Alternating Current Stimulation on Cerebral Tau Bur [PMID:34958021] | M. Dhaynaut, G. Sprugnoli, D. Cappon | {'name': "Journal of Alzheimer | 2021 | 0 |
| Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in tra [PMID:17021169] | ["Oakley, Holly", "Cole, Sarah L", "Loga | The Journal of neuroscience : | 2006 | 0 |
| The amyloid hypothesis of Alzheimer's disease: progress and problems on the road [PMID:12130773] | ["Hardy, John", "Selkoe, Dennis J"] | Science (New York, N.Y.) | 2002 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 6 · Score: 0.95 · 2026-04-27
closed · Rounds: 6 · Score: 0.95 · 2026-04-27
closed · Rounds: 4 · Score: 0.65 · 2026-04-27
closed · Rounds: 4 · Score: 0.71 · 2026-04-27
closed · Rounds: 4 · Score: 0.87 · 2026-04-27
closed · Rounds: 4 · Score: 0.48 · 2026-04-27
closed · Rounds: 4 · Score: 0.54 · 2026-04-27
closed · Rounds: 4 · Score: 0.19 · 2026-04-27
closed · Rounds: 4 · Score: 0.40 · 2026-04-27
closed · Rounds: 4 · Score: 0.50 · 2026-04-27
Hypotheses and analyses mentioning closed-loop tACS in their description or question text