Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about claudin_5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| tight_junctions | maintains | pathway | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CLDN5 | encodes | gene | 0.80 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
neurodegeneration | 2026-04-26 | 5 hypotheses Top: 0.712
neurodegeneration | 2026-04-16 | 7 hypotheses Top: 0.919
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.773
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
active · Rounds: 7 · Score: 0.00 · 2026-04-26
closed · Rounds: 4 · Score: 0.76 · 2026-04-23
closed · Rounds: 7 · Score: 0.87 · 2026-04-16
closed · Rounds: 4 · Score: 0.91 · 2026-04-06
Hypotheses and analyses mentioning claudin_5 in their description or question text
Score: 0.490 · unknown disease · 2026-04-26
Neuroinflammation triggers astrocyte and microglial MMP-9 activation, which proteolytically cleaves claudin-5, the princ
Score: 0.460 · neurodegeneration · 2026-04-25
HBOT promotes pericyte survival via PDGF-BB/PDGFR-β signaling and upregulates claudin-5 transcription through HIF-2α to