Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about cell_type: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Transcriptome | correlates_with | process | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| GPR37 | expressed_in | protein | 0.95 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
neurodegeneration | 2026-04-27 | 0 hypotheses
neurodegeneration | 2026-04-27 | 3 hypotheses Top: 0.626
neurodegeneration | 2026-04-27 | 3 hypotheses Top: 0.626
neurodegeneration | 2026-04-27 | 3 hypotheses Top: 0.626
neurodegeneration | 2026-04-27 | 4 hypotheses Top: 0.682
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Anti-ASC antibody intracerebroventricular injection in APP/PS1 mice | validation | Alzheimer's disease | 0.950 | 0.00 | APP/PS1 transgenic mice (8 mon | proposed | N/A |
| Curcumin-Licorice Combination in D-galactose/Sodium Nitrite AD Model | validation | Alzheimer's disease | 0.950 | 0.00 | C57BL/6 mice | proposed | N/A |
| SPP1 upregulation in perivascular cells in AD mouse models | exploratory | Alzheimer's disease | 0.900 | 0.00 | AD mouse models | proposed | N/A |
| Tet2 modulation in Aβ42-injured mouse hippocampal neurons | exploratory | Alzheimer's disease | 0.900 | 0.00 | primary mouse hippocampal neur | proposed | N/A |
| AAV-mediated Tet2 modulation in 2×Tg-AD mice behavioral study | validation | Alzheimer's disease | 0.900 | 0.00 | young APPswe/PSEN1 double-tran | proposed | N/A |
| Cerebrovascular function analysis in CD2AP mutant mice | validation | Alzheimer's disease | 0.900 | 0.00 | mice | proposed | N/A |
| Transcriptome sequencing of cardiac fibroblasts in TFEB overexpressing | exploratory | myocardial infarction | 0.900 | 0.00 | R26-LSL-TFEB+/+; Acta2-cre mic | proposed | N/A |
| Trehalose-induced lysosomal changes and TFEB activation | exploratory | motoneuron degeneration | 0.900 | 0.00 | NSC34 neuroblastoma x spinal c | proposed | N/A |
| Trehalose-induced lysosomal membrane permeabilization and TFEB activat | exploratory | motoneuron degeneration | 0.900 | 0.00 | NSC34 neuroblastoma cells | proposed | N/A |
| Cerebral blood flow regulation in CD2AP mutant mice | validation | Alzheimer's disease | 0.880 | 0.00 | mice | proposed | N/A |
| TFEB silencing and misfolded protein degradation | exploratory | motoneuron degeneration | 0.880 | 0.00 | NSC34 neuroblastoma x spinal c | proposed | N/A |
| Protein expression analysis and cell migration assays in cardiac fibro | exploratory | cardiac fibrosis | 0.880 | 0.00 | primary cardiac fibroblasts fr | proposed | N/A |
| Abeta-induced cell death and aggregation in GD3S-deficient neurons | exploratory | Alzheimer's disease | 0.850 | 0.00 | primary neurons and astrocytes | proposed | N/A |
| Generation of Aβ-specific Tregs using CRISPR-Cas9 | exploratory | Alzheimer's disease | 0.850 | 0.00 | engineered Tregs | proposed | N/A |
| Functional validation of trehalose effects on misfolded protein cleara | exploratory | motoneuron degeneration diseas | 0.850 | 0.00 | cell models expressing misfold | proposed | N/A |
| ChIP-qPCR validation of TFEB binding to Thbs1 promoter | exploratory | cardiac fibrosis | 0.850 | 0.00 | mouse cardiac fibroblasts | proposed | N/A |
| Trehalose analog testing for autophagy induction | exploratory | motoneuron degeneration | 0.820 | 0.00 | NSC34 neuroblastoma x spinal c | proposed | N/A |
| Cell-cell interaction analysis of perivascular-microglial crosstalk | exploratory | Alzheimer's disease | 0.800 | 0.00 | AD mouse models | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Transcriptomic cytoarchitecture reveals principles of human neocortex organizati [PMID:37824655] | Jorstad NL, Close J, Johansen N, Yanny A | Science | 2023 | 186 |
| Integrated multimodal cell atlas of Alzheimer’s disease [PMID:37292694] | Gabitto MI, Travaglini KJ, Rachleff VM, | Research Square | 2023 | 63 |
| Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2- [PMID:31932797] | Zhou Y, Song WM, Andhey PS, Swain A, Lev | Nat Med | 2020 | 1 |
| Moderate Effects of the Arginine to Histidine R47H Variant of the Triggering Rec [PMID:41890852] | ["Ramirez G", "Hernandez D", "Teal A", " | Research square | 2026 | 0 |
| Chemical and Molecular Strategies in Restoring Autophagic Flux in TDP-43 Protein [PMID:41900026] | Jamerlan A, Hulme J | Molecules (Basel, Switzerland) | 2026 | 0 |
| Mammalian lipophagy: process and function. [PMID:41681129] | Zhao R, Dai E, Kang R, Liu J, Klionsky D | Autophagy | 2026 | 0 |
| Increased plasma soluble TREM2 levels in non-Alzheimer's dementia. [PMID:41920402] | Güven Gamze; Gezegen Haşim; & | Acta neurologica Belgica | 2026 | 0 |
| Electroacupuncture regulates neuronal ferroptosis and ferritinophagy through lys [PMID:41272418] | Tang B, Xu X, Zhao W, Zhou Q, Du G et al | J Cereb Blood Flow Metab | 2026 | 0 |
| Endothelial Transcription Factor EB Protects Against Doxorubicin-Induced Endothe [PMID:41410033] | Du W, Ringer M, Desai D, Khandakar GI, T | Circulation | 2026 | 0 |
| Integrative Multiomics Insights into the Genetic and Epigenetic Architecture of [PMID:41422555] | Mishra AK, Jain S | ACS Chem Neurosci | 2026 | 0 |
| AI-guided design of cyclic peptide binders targeting TREM2 using CycleRFdiffusio [PMID:41435973] | Cho S, Zhu R, Kuncewicz K, Duan H, Gabr | Bioorg Med Chem Lett | 2026 | 0 |
| Proteotoxic stress triggers TFEB- and TFE3-mediated autophagy and lysosomal biog [PMID:41450115] | Zhu Z, Yang J, Montefusco S, Xia S, Ou J | Autophagy | 2026 | 0 |
| ITAM-Syk signaling mediates the rebound phenomenon after anti-RANKL antibody dis [PMID:41490759] | Ishizu H, Hasegawa T, Shimizu T, Yamamot | Bone | 2026 | 0 |
| Oxaliplatin-artesunate conjugate intensifies suppression on colorectal cancer by [PMID:41520444] | Tan Y, Yang T, Jiang S, Li S, Cai L et a | J Inorg Biochem | 2026 | 0 |
| The association of Alzheimer's disease-related SNPs with mild cognitive impairme [PMID:41606232] | Xie Z, Tu W, Ye XF, Hua L, Zhang X et al | Sci Rep | 2026 | 0 |
| Genetic risk factors of late-onset Alzheimer's disease: Insights into pathophysi [PMID:41622452] | Akkaoui J, Devadoss D, Rodriguez MD, Ari | Neural Regen Res | 2026 | 0 |
| Loss of Triggering Receptor Expressed on Myeloid Cells 2 Impairs Microglial Func [PMID:41643896] | Chen G, Wang Z, Zhao C, Wang C, Li Y et | Am J Pathol | 2026 | 0 |
| Microglial metabolic reprogramming in Alzheimer's disease: Pathways, mechanisms, [PMID:41651180] | Yang FG, Yang H, Han SW, Wang JT, Gao W | Ageing Res Rev | 2026 | 0 |
| Microglia TFEB activation attenuates Alzheimer's disease pathology by enhancing [PMID:41673711] | Kim Y, Ha TY, Kondaurova O, Lee MS, Chan | J Neuroinflammation | 2026 | 0 |
| Plant-derived bioactive compounds modulate the gut microbiota in Alzheimer's dis [PMID:41678917] | Xue D, Hu X, Li R, Sun T, Qian S et al. | Phytomedicine | 2026 | 0 |
Multi-agent debates referencing this entity
active · Rounds: 4 · Score: 0.64 · 2026-04-28
active · Rounds: 4 · Score: 0.67 · 2026-04-28
active · Rounds: 4 · Score: 0.67 · 2026-04-28
active · Rounds: 4 · Score: 0.67 · 2026-04-28
active · Rounds: 4 · Score: 0.67 · 2026-04-28
active · Rounds: 6 · Score: 0.89 · 2026-04-27
closed · Rounds: 6 · Score: 0.95 · 2026-04-27
closed · Rounds: 4 · Score: 0.12 · 2026-04-27
closed · Rounds: 4 · Score: 0.42 · 2026-04-27
closed · Rounds: 4 · Score: 0.48 · 2026-04-27
Hypotheses and analyses mentioning cell_type in their description or question text
Score: 0.626 · neurodegeneration · 2026-04-28
DPP6-linked neuronal regulatory networks controlling synaptic excitability and cognitive resilience in PD should produce
Score: 0.620 · neurodegeneration · 2026-04-04
## Mechanistic Overview Cross-Cell Type Synaptic Rescue via Tripartite Synapse Restoration starts from the claim that mo
Score: 0.612 · neurodegeneration · 2026-04-28
The question is likely underpowered or misleading unless analyses preserve the key strata: DPP6, GWAS. Averaging across
Score: 0.608 · neurodegeneration · 2026-04-28
The debate supports treating this as a validation program before ranking it as a therapy. Perturbation should move a pro
Score: 0.566 · neurodegeneration · 2026-04-22
## Mechanistic Overview Vascular and Perivascular Cell Type Vulnerability: BBB Integrity Disruption starts from the clai
Score: 0.510 · neurodegeneration · 2026-04-22
## Mechanistic Overview Tripartite Synapse Cell Type-Nonautonomous Crosstalk: Coordinated Failure starts from the claim
Score: 0.489 · molecular biology · 2026-04-21
## Mechanistic Overview Structured Intronic Scaffold Regions in Enhancer-dilncRNAs Enable Cell-Type Selective Targeting
Score: 0.369 · unknown disease · 2026-04-25
Concise Statement: GrimAge-derived epigenetic age acceleration, when deconvoluted for neuronal vs. glial cell-type prop