Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about axonal_RNA_transport: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| synaptic_function | maintains | pathway | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| HNRNPA2B1 | mediates | gene | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Axonal RNA Transport Reconstitution | 0.695 | neurodegeneration | RNA binding protein dysregulation across |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.720
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| s:** - Temporal analysis showing mitochondrial defects precede other p | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| Proposed experiment from debate on TDP-43 undergoes liquid-liquid phas | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| s:** - Single-cell RNA-seq to measure editing efficiency across differ | falsification | ALS | 0.400 | 0.50 | cell_line | proposed | $150,000 |
| ALS Progression Rate Heterogeneity — mechanism and biomarker predictor | clinical | ALS | 0.400 | 0.50 | human | proposed | $6,550,000 |
| ALS Regional Onset and Spread: Network-Level Staging Model | clinical | ALS | 0.400 | 0.50 | human | proposed | $7,500,000 |
| Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk Cohorts | clinical | ALS | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Axonal Transport Dysfunction Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Environmental Exposure Causal Attribution in ALS — Experiment Design | validation | ALS | 0.400 | 0.50 | human | proposed | $3,000,000 |
| Frontal and Temporal Lobe Selective Vulnerability in FTD — Mechanisms | validation | Neurodegeneration | 0.400 | 0.50 | human | proposed | $3,000,000 |
| FTLD-Tau vs FTLD-TDP In Vivo Biomarker Differentiation | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| SIRT6-regulated macrophage efferocytosis epigenetically controls inflammation re [PMID:36593966] | Li B, Xin Z, Gao S, Li Y, Guo S, Fu Y, X | Theranostics | 2023 | 1 |
| Multisystem proteinopathy: Where myopathy and motor neuron disease converge. [PMID:33145792] | Korb MK, Kimonis VE, Mozaffar T | Muscle Nerve | 2021 | 1 |
| The role of m6A modification in the biological functions and diseases. [PMID:33611339] | Jiang X, Liu B, Nie Z, Duan L, Xiong Q, | Signal Transduct Target Ther | 2021 | 1 |
| Tumor-derived exosomal miR-934 induces macrophage M2 polarization to promote liv [PMID:33213490] | Senlin Zhao, Yushuai Mi, Bingjie Guan, B | Journal of hematology & oncolo | 2020 | 1 |
| Rare Inherited forms of Paget's Disease and Related Syndromes. [PMID:30756140] | Ralston SH, Taylor JP | Calcif Tissue Int | 2019 | 1 |
| A LNK-CBL-HNRPA2B1-GPX4 signaling axis mediates dopaminergic neuron vulnerabilit [PMID:41616574] | ["Liu Z", "Wang R", "Shen M", "Lan X", " | Redox biology | 2026 | 0 |
| Human papillomavirus 16 E6 oncoprotein promotes up-regulation of RNA-binding pro [PMID:41725810] | ["Cerasuolo A", "Pecchillo Cimmino T", " | Frontiers in microbiology | 2026 | 0 |
| Molecular recognition and induced dimerization of hnRNP A2/B1 truncations by G-q [PMID:41888191] | ["Shahatibieke D", "Tang X", "Zheng X", | Scientific reports | 2026 | 0 |
| LncRNA 4930544M13Rik-201 regulates CACNA2D1 expression via interacting with hnRN [PMID:41864512] | Fang Z, Liu F, Tang Q, Liu Y, Peng Y, Zh | Brain research bulletin | 2026 | 0 |
| Comparative Binding Analysis by Computational Methods and Quartz Crystal Microba [PMID:41728844] | ["Volkova O", "Serova A", "Kravtsov V", | Journal of chemical informatio | 2026 | 0 |
| Functional Variants of the RAD51 Gene Contribute to Susceptibility to Non-Syndro [PMID:41918261] | Guo S, Guo T, Xu Y, Chen R, Wang X | Orthodontics & craniofacial re | 2026 | 0 |
| Ligand-specific conformational dynamics and interaction landscapes of hnRNPA2B1 [PMID:41853685] | Zhou Z, Li Y, Yang P, Zhu R, Li J, Wu B, | Current research in structural | 2026 | 0 |
| Neddylation-Mediated hnRNPA2B1 Degradation Aggravates Retinal Endothelial Cell D [PMID:41773772] | Chen TR, Zhou JX, Hou YR, Zhang YN, Li C | Investigative ophthalmology & | 2026 | 0 |
| Mechanistic studies on HNRNPA2B1 suggest binding but not selective recognition o [PMID:41662154] | ["Park R", "Demny M", "Miller L", "Pedra | RNA biology | 2026 | 0 |
| Network medicine modeling of the m⁶A regulatory landscape identifies a KLF6-WTAP [PMID:41787499] | Xu C, Zhou Z, Lin Y, Zhang S, Cai S, Li | Journal of translational medic | 2026 | 0 |
| Integrative transcriptome-wide association analyses reveal PRKCG-linked GABAergi [PMID:41507195] | ["Jin Y", "Cao Y", "Ma W", "Li R", "Li Y | Nature communications | 2026 | 0 |
| The Intersection of m6A Methylation and Immune Response in PCOS: A Bioinformatic [PMID:41725222] | ["Xu W", "Shi L", "Lu A", "Cui L", "Qian | Immunity, inflammation and dis | 2026 | 0 |
| Expression, purification, and biophysical characterization of liquid-liquid phas [PMID:41297573] | ["Dur\u00e1n-Armenta L", "Meszaros A", " | Protein expression and purific | 2026 | 0 |
| Interaction of tau with HNRNPA2B1 and N6-methyladenosine RNA mediates the progre [PMID:34453888] | Jiang L, Lin W, Zhang C, Ash PEA, Verma | Molecular cell | 2021 | 0 |
| Stress granule mediated protein aggregation and underlying gene defects in the F [PMID:31626953] | Baradaran-Heravi Y, Van Broeckhoven C, v | Neurobiology of disease | 2020 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.72 · 2026-04-12
closed · Rounds: 4 · Score: 0.88 · 2026-04-06
Hypotheses and analyses mentioning axonal_RNA_transport in their description or question text
No additional research found