protein

APOE3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about APOE3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

591Connections

4Hypotheses

2Analyses

50Outgoing

50Incoming

10Experiments

2Debates

Summary

APOE3 is a protein involved in neurodegeneration research. Key relationships include: activates, expressed in, associated with. Associated with ALS, Aging, Als. Connected to 273 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	APOE3
Aliases	apoe3
Associated Diseases	Aging, Als, Alzheimer, Alzheimer's disease
Interactions	ABCA1, ACAT1, Actin, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE
KG Connections	591 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

APOE3 (Apolipoprotein E3)

disease · 943 words

→

Adenine Base Editing of APOE4 to APOE3 for Alzheimer's Prevention

idea · 705 words

→

Pathway Diagram

graph TD
    APOE3["APOE3"] -->|"protects against"| amyloid_pathology["amyloid pathology"]
    APOE3["APOE3"] -.->|"inhibits"| vessel_associated_gliosis["vessel-associated gliosis"]
    APOE3["APOE3"] -->|"causes"| retinal_ganglion_cell_loss["retinal ganglion cell loss"]
    APOE3["APOE3"] -->|"contributes to"| glaucoma["glaucoma"]
    APOE3["APOE3"] -->|"regulates"| tau_pathology["tau pathology"]
    APOE3["APOE3"] -->|"protects against"| Alzheimer_s_disease["Alzheimer's disease"]
    ABCA1["ABCA1"] -->|"associated"| APOE3["APOE3"]
    APOE["APOE"] -->|"activates"| APOE3["APOE3"]
    APOE__4_ALLELE["APOE Epsilon4 ALLELE"] -->|"therapeutic target"| APOE3["APOE3"]
    APOE4["APOE4"] -->|"associated"| APOE3["APOE3"]
    style APOE3 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (420)

Target	Relation	Type	Str
Alzheimer	activates	disease	1.00
APOE4	activates	gene	1.00
APOE	activates	gene	1.00
Alzheimer	protects_against	disease	0.95
Neurodegeneration	activates	disease	0.95
Als	activates	disease	0.95
dystrophic neurites	protects_against	phenotype	0.92
LDLR binding	impairs	process	0.90
amyloid pathology	protects_against	phenotype	0.90
ALZHEIMER'S DISEASE	activates	gene	0.90
ALZHEIMER'S DISEASE	protects_against	gene	0.90
AMYLOID	activates	gene	0.90
Stem Cell	activates	pathway	0.90
ALZHEIMER	activates	gene	0.90
Alzheimer's Disease	associated_with	disease	0.88
APOE4	inhibits	protein	0.85
Alzheimer	expressed_in	disease	0.85
LRP8	activates	protein	0.85
oxidative stress response	participates_in	pathway	0.85
intracellular lipid homeostasis	associated_with	process	0.85
LDLR	binds	protein	0.80
vessel-associated gliosis	inhibits	phenotype	0.80
neurite damage	inhibits	pathway	0.80
retinal ganglion cell loss	causes	phenotype	0.80
glaucoma	contributes_to	disease	0.80
Alzheimer's Disease	protects_against	disease	0.80
ALZHEIMER	expressed_in	gene	0.80
ALZHEIMER	protects_against	gene	0.80
synaptic plasticity	participates_in	pathway	0.75
Alzheimer	associated_with	disease	0.75
Neurodegeneration	protects_against	disease	0.75
Als	interacts_with	disease	0.75
Tauopathy	activates	disease	0.75
DAM microglia	expressed_in	cell_type	0.75
Alzheimer	regulates	disease	0.75
cholesterol	modulates	compound	0.70
tau pathology	regulates	process	0.70
APOE	regulates	gene	0.70
AUTOPHAGY	activates	gene	0.70
Autophagy	activates	pathway	0.70
ALZHEIMER'S DISEASE	regulates	gene	0.70
astrocytes	expressed_in	cell_type	0.70
ALZHEIMER	associated_with	gene	0.70
TAUOPATHY	activates	gene	0.70
stem cells	expressed_in	cell_type	0.70
APOE	interacts_with	gene	0.70
APOE4	interacts_with	gene	0.70
Alzheimer's disease	protects_against	disease	0.70
TAU PATHOLOGY	protects_against	gene	0.70
APP	activates	gene	0.70

Incoming (171)

Source	Relation	Type	Str
NEURODEGENERATION	activates	gene	0.90
TREM2 R47H	affects	gene	0.80
NEURODEGENERATION	protects_against	gene	0.70
TAU	activates	gene	0.70
APOE2	associated_with	gene	0.70
ALZHEIMER'S DISEASE	expressed_in	gene	0.70
NEURON	activates	gene	0.70
APOE	targets	gene	0.65
APOE2	targets	gene	0.65
APOE	protects_against	gene	0.65
APOE2	protects_against	gene	0.65
APOE	associated_with	gene	0.65
APOE	regulates	gene	0.65
APOE4	associated_with	gene	0.60
APOE4	inhibits	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
TAU	inhibits	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
APOE Ε4	associated_with	gene	0.60
ABCA1	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
JUN	activates	gene	0.60
APOE4	activates	gene	0.60
AMYLOID-Β PLAQUES	implicated_in	gene	0.60
MIRNAS	regulates	gene	0.60
ACETYL-COA	regulates	gene	0.60
ALZHEIMER DISEASE	associated_with	gene	0.60
LYSOSOME	activates	gene	0.60
PARKINSON'S DISEASE	implicated_in	gene	0.60
NEURODEGENERATIVE DISEASES	implicated_in	gene	0.60
INFLAMMATION	implicated_in	gene	0.60
APOE4	expressed_in	gene	0.60
BRAIN INJURY	implicated_in	gene	0.60
PARKINSON	implicated_in	gene	0.60
AUTOPHAGY	implicated_in	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	implicated_in	gene	0.60
APOE	expressed_in	gene	0.60
ABCA7	protects_against	gene	0.60
TAU	expressed_in	gene	0.60
GAIN	expressed_in	gene	0.60
NEURON	expressed_in	gene	0.60
AND	activates	gene	0.60
APP	activates	gene	0.60
RANK	activates	gene	0.60
ALZHEIMER	protects_against	gene	0.60
DLK	activates	gene	0.60
TAU PATHOLOGY	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
LDLR	inhibits	gene	0.60
APOE4	protects_against	gene	0.60

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Prime Editing Precision Correction of APOE4 to APOE3 in Micr	0.803	neurodegeneration	CRISPR-based therapeutic approaches for
Targeted APOE4-to-APOE3 Base Editing Therapy	0.758	neurodegeneration	APOE4 structural biology and therapeutic
AAV-Mediated APOE2/APOE3 Gene Delivery to Convert APOE Genot	0.700	neurodegeneration	APOE4 targeting in neurodegeneration
H6: Epigenetic Reset via APOE4→APOE3 Conversion Reverses Sen	0.540	neurodegeneration	Do APOE4-driven senescent astrocytes cau

Mentioning Analyses (2)

Scientific analyses that reference this entity

APOE4 targeting in neurodegeneration

neurodegeneration | 2026-04-02 | 4 hypotheses Top: 0.720

APOE4 structural biology and therapeutic targeting strategies

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.795

Experiments (10)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
RBG treatment in ApoE-/- atherosclerosis mouse model	validation	atherosclerosis	0.900	0.00	ApoE-/- mice	proposed	N/A
s:** - Biochemical binding assays measuring PROTAC selectivity for APO	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$100,000
AD Combination Therapy Trial: Anti-Aβ + Anti-Tau	clinical	Alzheimer's Disease	0.400	0.50	cell_line	proposed	$180,000
Why Does Amyloid Removal Only Slow Decline 27%? — Mechanistic investig	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$7,100,000
ApoE4 Function in Alzheimer's Disease	validation	Alzheimer's Disease	0.400	0.50	mouse	proposed	$360,000
Biomarker-Guided Sequential Therapy Selection in Alzheimer's Disease	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
Blood-Based Biomarker Panel for Early AD Detection	clinical	Alzheimer's Disease	0.400	0.50	cell_line	proposed	$220,000
CRISPR Gene Correction Approaches for CBS/PSP	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
Down Syndrome Alzheimer's Disease: Mechanisms and Therapeutic Timing	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$7,500,000
Sex Differences in Alzheimer's Disease — mechanisms and therapeutic im	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$7,500,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
An AAV capsid reprogrammed to bind human transferrin receptor mediates brain-wid [PMID:38753766]	Huang Q, Chan KY, Wu J, Botticello-Romer	Science	2024	1
ApoE in Alzheimer's disease: pathophysiology and therapeutic strategies. [PMID:36348357]	Raulin AC, Doss SV, Trottier ZA, Ikezu T	Mol Neurodegener	2022	1
APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therape [PMID:33340485]	Serrano-Pozo A, Das S, Hyman BT	Lancet Neurol	2021	1
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies. [PMID:31564456]	Long JM, Holtzman DM	Cell	2019	1
Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies. [PMID:31367008]	Yamazaki Y, Zhao N, Caulfield TR, Liu CC	Nat Rev Neurol	2019	1
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Mic [PMID:28930663]	Krasemann S, Madore C, Cialic R, Baufeld	Immunity	2017	1
Modulating LRP1 Pathways in Alzheimer's Disease: Mechanistic Insights and Emergi [PMID:41772271]	Mushtaq T, Hameed H, Khan MA, Tariq U, H	Molecular neurobiology	2026	0
CRISPR-based correction of apolipoprotein E4 in Alzheimer's disease: Therapeutic [PMID:41812941]	["Wang M", "Niu D", "Zhang Q", "Tang Y",	International journal of biolo	2026	0
Perioperative polygenic and APOE-based genetic risk assessment for neurocognitiv [PMID:40562635]	Thedim M, Hu J, Maher M, Wiener-Kronish	Br J Anaesth	2026	0
Increased genetic protection against Alzheimer's disease in centenarians. [PMID:40615639]	Bae H, Song Z, Ali A, Sasaki T, Tesi N e	Geroscience	2026	0
Integrative machine learning approach to risk prediction for dementia and Alzhei [PMID:40864401]	Stern A, Linial M	Geroscience	2026	0
Adipose Tissue Macrophage-Derived Proplatelet Basic Protein Exacerbates Psoriasi [PMID:40886963]	Zhu L, Du L, Wu J, Ding D, Wang J et al.	J Invest Dermatol	2026	0
Macrophagic Sclerostin Loop2-ApoER2 Interaction Required by Sclerostin for Cardi [PMID:41276911]	Wang L, Tao X, Zhang N, Yang X, Jiang H	Adv Sci (Weinh)	2026	0
APOE Genotype Modulates the Relationship of Stroke With Dementia Risk: Associati [PMID:41404739]	Zhang CH, Huang LY, Feng YG, Tan CC, Tan	J Am Heart Assoc	2026	0
High- and Low-Fat Dairy Consumption and Long-Term Risk of Dementia: Evidence Fro [PMID:41406402]	Du Y, Borné Y, Samuelsson J, Glans I, Hu	Neurology	2026	0
Targeting KAT8 alleviates vascular senescence by modulating the INHBA/TGF-β path [PMID:41445196]	Lin Z, Xiong J, Zhang F, Zhang H, Zhu M	Mol Ther	2026	0
Prime Editing of Alzheimer's Disease High-Risk APOE4 Allele by Brain-Directed Ad [PMID:41449667]	Günaydin C, Hackett NR, Wakim V, Sondhi	Hum Gene Ther	2026	0
The role of astrocytes in Alzheimer's disease: Pathophysiology, biomarkers, and [PMID:41527736]	Abedin MJ, Kastanenka KV	J Alzheimers Dis	2026	0
Menopause, cognition, and Alzheimer's disease risk. [PMID:41531227]	Samudra N, Vemuri M, Weitlauf J	Curr Opin Obstet Gynecol	2026	0
Endothelial TBK1 Deficiency Inhibits Endothelial-to-Mesenchymal Transition and A [PMID:41685426]	Pu Y, Dong P, He L, Huang J, Wu Y et al.	Circ Res	2026	0

Debates (2)

Multi-agent debates referencing this entity

What are effective therapeutic strategies for targeting APOE4 in Alzheimer's dis

closed · Rounds: 4 · Score: 0.82 · 2026-04-22

APOE4 differs from APOE3 by C112R causing domain interaction that alters lipid b

closed · Rounds: 4 · Score: 0.89 · 2026-04-06

Related Research

Hypotheses and analyses mentioning APOE3 in their description or question text

No additional research found