Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about aging-neurodegeneration: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | aging-neurodegeneration |
Knowledge base pages for this entity
graph TD
A["Upstream trigger"] --> B["aging neurodegeneration"]
B --> C["Molecular cascade"]
C --> D["Cellular dysfunction"]
D --> E["Neuronal death"]
B --> F["Inflammatory response"]
F --> D
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
class B mechanism
class E disease| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| entities-dna-methylation | involved_in | wiki | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Myelin Breakdown-Amyloid Interaction Amplifies Cortical Agin | 0.512 | Alzheimer disease | Allen Mouse Brain Aging Atlas: cross-age |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-23 | 8 hypotheses Top: 0.519
neurodegeneration | 2026-04-12 | 0 hypotheses
neurodegeneration | 2026-04-03 | 43 hypotheses Top: 0.893
neurodegeneration | 2026-04-03 | 0 hypotheses
neurodegeneration | 2026-04-03 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Discovery of an APP-selective BACE1 inhibitor for Alzheimer's disease. [PMID:40399225] | Unknown | Neurotherapeutics : the journa | 2025 | 0 |
| Discovery of an APP-selective BACE1 inhibitor for Alzheimer's disease. [PMID:40399225] | Campagna, Jagodzinska, Wi, Zhu, Lee et a | Neurotherapeutics : the journa | 2025 | 0 |
| Amyloid fibrils of the myelin basic protein are an integral component of myelin [PMID:40781105] | Sysoev EI, Shenfeld AA, Belashova TA | Sci Rep | 2025 | 0 |
| β-asarone improves cognitive impairment and alleviates autophagy in mice with va [PMID:38039902] | Ning, Zhong, Wu, Wang, Hu et al. | Phytomedicine : international | 2024 | 0 |
| Myelin basic protein mRNA levels affect myelin sheath dimensions, architecture, [PMID:39023138] | Bagheri H, Friedman H, Hadwen A | Glia | 2024 | 0 |
| β-asarone improves cognitive impairment and alleviates autophagy in mice with va [PMID:38039902] | Unknown | Phytomedicine : international | 2024 | 0 |
| Myelin basic protein and index for neuro-Behçet's disease. [PMID:36907539] | Zhan H, Cheng L, Wang X | Clin Immunol | 2023 | 0 |
| The Effect of Mindfulness-based Programs on Cognitive Function in Adults: A Syst [PMID:34350544] | Whitfield, Barnhofer, Acabchuk, Cohen, L | Neuropsychology review | 2022 | 0 |
| Multiple sclerosis and myelin basic protein: insights into protein disorder and [PMID:34889995] | Martinsen V, Kursula P | Amino Acids | 2022 | 0 |
| The Effect of Mindfulness-based Programs on Cognitive Function in Adults: A Syst [PMID:34350544] | Whitfield Tim; Barnhofer Thorsten; Acabc | Neuropsychology review | 2021 | 0 |
| An update on diagnostic and prognostic biomarkers for traumatic brain injury. [PMID:29338452] | Unknown | Expert review of molecular dia | 2019 | 0 |
| An update on diagnostic and prognostic biomarkers for traumatic brain injury. [PMID:29338452] | Unknown | Expert review of molecular dia | 2019 | 0 |
| An updated histological classification system for multiple sclerosis lesions. [PMID:27988845] | Kuhlmann T, Ludwin S, Prat A | Acta Neuropathol | 2017 | 0 |
| What do your eyes reveal about your foreign language? Reading emotional sentence [PMID:28973016] | Iacozza Sara; Costa Albert; Duñabei | PloS one | 2017 | 0 |
| What do your eyes reveal about your foreign language? Reading emotional sentence [PMID:28973016] | ["Iacozza, Sara", "Costa, Albert", "Du\u | PloS one | 2017 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 1.00 · 2026-04-24
closed · Rounds: 4 · Score: 0.50 · 2026-04-18
closed · Rounds: 4 · Score: 0.95 · 2026-04-03
closed · Rounds: 4 · Score: 0.95 · 2026-04-03
closed · Rounds: 4 · Score: 0.95 · 2026-04-03
closed · Rounds: 4 · Score: 0.71 · 2026-04-02
closed · Rounds: 4 · Score: 0.43 · 2026-04-02
closed · Rounds: 4 · Score: 0.50 · 2026-04-02
closed · Rounds: 4 · Score: 0.57 · 2026-04-02
closed · Rounds: 4 · Score: 0.56 · 2026-04-02
Hypotheses and analyses mentioning aging-neurodegeneration in their description or question text
No additional research found