Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about aged neurons: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| TET function impairment | causes | mechanism | 0.70 |
| Reduced α-KG/succinate ratio | associated_with | mechanism | 0.70 |
| Methylation drift at synaptic plasticity genes | causes | phenotype | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| H3K9me3 reduction | associated_with | biomarker | 0.90 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| mTORC1 Displacement from Lysosomal Membrane Enables TFEB Nuc | 0.640 | neurodegeneration | - |
| P2Y6R activation by UDP from damaged neurons drives microgli | 0.540 | neurodegeneration | Which tau propagation mechanism predomin |
Scientific analyses that reference this entity
epigenetics | 2026-04-15 | 0 hypotheses
neurodegeneration | 2026-04-10 | 7 hypotheses Top: 0.700
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.50 · 2026-04-21
closed · Rounds: 0 · Score: 0.48 · 2026-04-21
closed · Rounds: 0 · Score: 0.51 · 2026-04-21
closed · Rounds: 4 · Score: 0.73 · 2026-04-21
closed · Rounds: 4 · Score: 0.95 · 2026-04-16
Hypotheses and analyses mentioning aged neurons in their description or question text
No additional research found