Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about adamts13: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ADAMTS13 |
| Full Name | A Disintegrin And Metalloproteinase with Thrombospondin Motifs 13 |
| Chromosome | 9q34.2 |
| Protein Type | Protease |
| Function | ADAMTS13 is a zinc-dependent metalloprotease that specifically cleaves von Willebrand factor (VWF) multimers into smaller, less pro-thrombotic units. |
| Primary Expression | the liver, particularly by hepatic stellate cells and endothelial cells [2] |
| UniProt ID | https://www.uniprot.org/uniprot/Q76LX8 Q76LX8 |
| Ensembl ID | ENSG00000162825 |
| GeneCards | ADAMTS13 |
| Human Protein Atlas | ADAMTS13 |
| Liver | Primary site of synthesis (hepatocytes and hepatic stellate cells) |
| Brain | Cerebral microvascular endothelial cells, astrocytes |
| Kidney | Glomerular endothelial cells |
| Plasma | Circulating enzyme at concentrations of ~1 μg/mL |
| Recombinant ADAMTS13 | Being developed for congenital TTP; potential neuroprotective therapy |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
A["Regulatory elements"] --> B["adamts13 gene"]
B --> C["mRNA transcript"]
C --> D["Protein product"]
D --> E["Cellular function"]
E --> F["Disease relevance"]
B --> G["Variant effects"]
G --> F
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
class B gene
class D protein| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:ADAMTS13 | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:ADAMTS13 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning adamts13 in their description or question text
No additional research found