Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about XRCC5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | XRCC5 |
| Full Name | X-Ray Repair Cross Complementing 5 |
| Chromosome | 2q33.3 |
| Function | The XRCC5 gene encodes Ku80 (also known as Ku80 or GARP22), a key protein in the non-homologous end joining (NHEJ) pathway of DNA double-strand break repair. |
| Primary Expression | most tissues with highest levels in: |
| UniProt ID | P13010 |
| NCBI Gene ID | 7520 |
| Ensembl ID | ENSG00000179295 |
| OMIM | 194370 |
| GeneCards | XRCC5 |
| Human Protein Atlas | XRCC5 |
| Brain | Neurons and glial cells, particularly in the hippocampus and cortex |
| Lymphoid tissues | High proliferative activity |
| Liver | Metabolic activity |
| Associated Diseases | neurodegeneration |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
XRCC5["XRCC5 (Ku80)"]
SOX2["SOX2"]
DNA_damage["DNA Double-Strand Breaks"]
NHEJ["Non-Homologous End Joining"]
DNA_repair["DNA Repair"]
Ku70["Ku70 (XRCC6)"]
DNA_PKcs["DNA-PKcs"]
Neurodegeneration["Neurodegeneration"]
Oxidative_stress["Oxidative Stress"]
Aging_neurons["Aging Neurons"]
Cell_death["Neuronal Cell Death"]
Genomic_instability["Genomic Instability"]
Neural_stem_cells["Neural Stem Cells"]
Neuronal_survival["Neuronal Survival"]
DNA_damage -->|"activates"| XRCC5
XRCC5 -->|"forms complex with"| Ku70
Ku70 -->|"recruits"| DNA_PKcs
DNA_PKcs -->|"facilitates"| NHEJ
NHEJ -->|"promotes"| DNA_repair
DNA_repair -->|"protects"| Neuronal_survival
XRCC5 -->|"deficiency leads to"| Genomic_instability
Genomic_instability -->|"causes"| Neurodegeneration
Oxidative_stress -->|"induces"| DNA_damage
Aging_neurons -->|"accumulates"| DNA_damage
SOX2 -->|"interacts with"| XRCC5
SOX2 -->|"maintains"| Neural_stem_cells
Genomic_instability -->|"triggers"| Cell_death
Cell_death -->|"contributes to"| Neurodegeneration
classDef central fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
classDef protective fill:#1a3a2a,stroke:#81c784,stroke-width:2px,color:#fff
classDef pathological fill:#3a1a1a,stroke:#ef5350,stroke-width:2px,color:#fff
classDef regulatory fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px,color:#fff
classDef disease fill:#3a2a1a,stroke:#ffa726,stroke-width:2px,color:#fff
class XRCC5 central
class DNA_repair,NHEJ,Neuronal_survival protective
class DNA_damage,Genomic_instability,Cell_death,Oxidative_stress pathological
class SOX2,Ku70,DNA_PKcs,Neural_stem_cells regulatory
class Neurodegeneration,Aging_neurons disease| Target | Relation | Type | Str |
|---|---|---|---|
| Nonhomologous End Joining | involved_in | pathway | 0.95 |
| Source | Relation | Type | Str |
|---|---|---|---|
| DNA double-strand breaks | activates | process | 0.90 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning XRCC5 in their description or question text
No additional research found