gene

XK

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about XK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

8Connections

0Hypotheses

0Analyses

8Outgoing

0Incoming

0Experiments

0Debates

Summary

XK encodes a membrane protein forming the Kell blood group system precursor, crucial for neuronal health. Mutations cause McLeod syndrome, a Huntington's disease phenocopy.

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🧬 Gene Info

Gene Symbol	XK
Full Name	XK, Kell Blood Group Precursor
Chromosome	Xp21.1
Function	XK plays several important roles in neuronal health
Primary Expression	various tissues including neurons
Molecular Weight	41 kDa
Amino Acids	404 aa
Exons	4
UniProt ID	[P51810](https://www.uniprot.org/uniprot/P51810)
GeneCards	XK
Human Protein Atlas	XK
Transmembrane domains	10 predicted transmembrane helices
N-linked glycosylation sites	Multiple sites in the extracellular loops
Kell blood group epitopes	The XK protein carries Kell antigens
Associated Diseases	McLeod_syndrome, neurodegeneration
Interactions	VPS13A
KG Connections	8 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

XK Gene

gene · 1658 words

→

XK Protein

protein · 695 words

→

Pathway Diagram

graph TD
    XK["XK"]
    VPS13A["VPS13A"]
    XK -->|"interacts with"| VPS13A
    phosphatidylserine["phosphatidylserine"]
    XK -->|"regulates"| phosphatidylserine
    McLeod_syndrome{"McLeod_syndrome"}
    XK -->|"causes"| McLeod_syndrome
    neurodegeneration{"neurodegeneration"}
    XK -->|"associated with"| neurodegeneration
    acanthocytes["acanthocytes"]
    XK -->|"associated with"| acanthocytes
    basal_ganglia["basal_ganglia"]
    XK -->|"associated with"| basal_ganglia
    lipid_processing["lipid_processing"]
    XK -->|"participates in"| lipid_processing
    lipid_trafficking["lipid_trafficking"]
    XK -->|"participates in"| lipid_trafficking
    XK -->|"implicated in"| neurodegeneration
    style XK fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (8)

Target	Relation	Type	Str
VPS13A	interacts_with	gene	0.90
phosphatidylserine	regulates	entity	0.90
McLeod_syndrome	causes	disease	0.90
neurodegeneration	associated_with	disease	0.80
acanthocytes	associated_with	cell_type	0.80
basal_ganglia	associated_with	brain_region	0.80
lipid_processing	participates_in	process	0.70
lipid_trafficking	participates_in	process	0.70

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning XK in their description or question text

No additional research found