Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about UT-B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
| Target | Relation | Type | Str |
|---|---|---|---|
| Water Transport | mediates | process | 0.90 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Gut-BBB Axis: Tributyrin/Butyrate HDAC Inhibition Epigenetic | 0.712 | - | Blood-brain barrier permeability changes |
| TLR4/MyD88/NF-κB Axis Blockade to Interrupt LPS-Mediated Gut | 0.703 | neurodegeneration | How do gut microbiome-derived metabolite |
| Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain A | 0.669 | neurodegeneration | What are the mechanisms by which gut mic |
| Gut-Brain Axis M-Cell Modulation | 0.629 | - | Neuroinflammation and microglial priming |
| Gut-Brain Axis Microbiome Modulation | 0.557 | Alzheimer's disease | Neuroinflammation and microglial priming |
| Gut-Brain Axis Microglial Depriming Strategy | 0.000 | - | Neuroinflammation and microglial priming |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Electroacupuncture ST37 treatment for DSS-induced colitis in mice | validation | colitis | 0.950 | 0.00 | mice | proposed | N/A |
| HFD-induced cognitive dysfunction and neuroinflammation in mice | validation | diet-induced cognitive dysfunc | 0.900 | 0.00 | adult Swiss male mice | proposed | N/A |
| α7nAChR agonist treatment rescues HFD-induced memory deficits | validation | diet-induced cognitive dysfunc | 0.850 | 0.00 | HFD-fed adult Swiss male mice | proposed | N/A |
| AhR transcriptional regulation of NEP gene | exploratory | Alzheimer's disease | 0.850 | 0.00 | Cell culture system | proposed | N/A |
| α7nAChR knockout mice show enhanced HFD sensitivity | validation | diet-induced cognitive dysfunc | 0.800 | 0.00 | Chrna7 knockout mice | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Pseudostellaria heterophylla polysaccharide mitigates Alzheimer's-like pathology [PMID:38750854] | He C, Jiang J, Liu J, Zhou L, Ge Y, Yang | International journal of biolo | 2024 | 1 |
| Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Ca [PMID:35642214] | Wang M, Pan W, Xu Y, Zhang J, Wan J, Jia | J Inflamm Res | 2022 | 1 |
| Astrocytic α7-nicotinic acetylcholine receptors mediate pain information process [PMID:41453579] | Teng T, Yang S, Li J, Wang H, Wu F, He Y | Neurobiology of disease | 2026 | 0 |
| Signal-Level Determinants of Cognitive Decline With PPIs versus H2RAs: Transport [PMID:41663888] | Saihati HAA, Ahmed BY, Mosaad RM, El-Gar | Molecular nutrition & food res | 2026 | 0 |
| Therapeutic strategies for hypertension: exploring the role of microbiota-derive [PMID:40637840] | Tortelote GG | Pediatr Nephrol | 2026 | 0 |
| Exploring the gut-kidney axis: Berberine's role in alleviating chronic kidney di [PMID:41344525] | Lu Z, Li Z, Gu S, Cai Y, Wu Y et al. | J Ethnopharmacol | 2026 | 0 |
| Rebalancing the inflammatory niche in allergic rhinitis ". [PMID:41360358] | Wang N, Tang Y | Clin Chim Acta | 2026 | 0 |
| Differentiating Damp-Heat and Cold-Damp Diarrhea in Rat Models via Gut Microbiot [PMID:41566926] | Zhang H, Song X, Mi W, Ji P, Wei Y et al | Microbiologyopen | 2026 | 0 |
| Nicotine Suppresses Human Memory Th Cell Subsets With Preferential Effects on Ce [PMID:41928597] | Gholizadeh F, Hajiaghayi M, Rahbari N, C | Eur J Immunol | 2026 | 0 |
| Alpha 7 nicotinic acetylcholine receptor contributes to long-term cognitive reco [PMID:41270982] | Nguyen DT, Mendoza K, Hall C, Tan C, Cha | Experimental neurology | 2026 | 0 |
| Putative α7-selective ligands interact with α9-containing nicotinic acetylcholin [PMID:41890755] | Mobasher M, Hone AJ, Pilzecker M, Bozic | Frontiers in immunology | 2026 | 0 |
| Short-term exposure to a high-fat diet leads to neuroinflammation and impairs me [PMID:41565126] | Costa SO, Silva IM, Chaves WF, Esteves A | The Journal of nutritional bio | 2026 | 0 |
| Acetylcholine enhances HIF-1α signaling in pancreatic cancer cells under hypoxia [PMID:41608625] | Cho Y, Kim HG, Kang JH, Oh ET, Park HJ | International journal of biolo | 2026 | 0 |
| Cranberry extract-supplemented microbiota effluents enhance intestinal barrier i [PMID:41680408] | Cattero V, Mayer T, Veilleux A, Roussel | Scientific reports | 2026 | 0 |
| Exploring the Role of Microglial Cells in the Gut-Brain Axis Communication: A Sy [PMID:40662222] | Ortiz-Samur NS, Vijaya AK, Burokas A, Me | Journal of neurochemistry | 2025 | 0 |
| Central-peripheral neuroimmune dynamics in psychological stress and depression: [PMID:40610703] | Feng X, Jia M, Cai M, Zhu T, Hashimoto K | Molecular psychiatry | 2025 | 0 |
| The ATP-mediated cytokine release by macrophages is down-modulated by unconventi [PMID:41221292] | Wolf PMK, Hanke D, Singh VK, Keller HL, | Frontiers in immunology | 2025 | 0 |
| Vagus nerve stimulation as a promising neuroprotection for ischemic stroke via α [PMID:38504011] | Xia XM, Duan Y, Wang YP, Han RX, Dong YF | Acta Pharmacol Sin | 2024 | 0 |
| Splenic nerve denervation attenuates depression-like behaviors in Chrna7 knock-o [PMID:38944290] | ["Yang Y", "Eguchi A", "Mori C", "Hashim | Journal of affective disorders | 2024 | 0 |
| Microglia and gut microbiota: A double-edged sword in Alzheimer's disease. [PMID:39321881] | Bano N, Khan S, Ahamad S, Kanshana JS, D | Ageing research reviews | 2024 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning UT-B in their description or question text