protein

USH1GPROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about USH1GPROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

USH1G is a modular scaffolding protein characterized by multiple protein-protein interaction domains that enable it to assemble multi-protein complexes essential for mechanotransduction and cellular signaling.

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🔬 Protein Info

Gene Symbol	USH1GPROTEIN
Chromosome	17q25.1
Function	is a scaffolding protein essential for hair cell stereocilia formation in the inner ear and for neuronal function in the central nervous system.
Molecular Weight	460 kDa
GeneCards	USH1GPROTEIN
Human Protein Atlas	USH1GPROTEIN
Hair Bundle Formation	Coordinates the development and maintenance of stereocilia bundles
Tip Link Assembly	Assembles the tip links that connect stereocilia and gate the mechanotransduction channel
Myosin-based Transport	Works with myosin VIIa to transport protein complexes along actin filaments
Signal Transduction	Converts mechanical force to electrical signals via the mechanotransduction channel
Synapse Formation	Organizes ribbon synapses for neurotransmitter release
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

USHER Syndrome 1G Protein

protein · 1619 words

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Pathway Diagram

graph TD
    USH1GPROTEIN["USH1GPROTEIN"]
    neurodegeneration["neurodegeneration"]
    USH1GPROTEIN -->|"implicated_in"| neurodegeneration
    style USH1GPROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning USH1GPROTEIN in their description or question text

No additional research found