gene

UNC13B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about UNC13B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

4Connections

0Hypotheses

0Analyses

4Outgoing

0Incoming

0Experiments

0Debates

Summary

UNC13B encodes Munc13-2, a critical synaptic protein involved in synaptic vesicle priming, neurotransmitter release, and short-term plasticity. Implicated in Alzheimer's disease, Parkinson's disease, and epilepsy.

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🧬 Gene Info

Gene Symbol	UNC13B
Full Name	UNC13 Homolog B
Chromosome	9p13.3
Molecular Weight	200 kDa
Amino Acids	735 aa
Exons	37
UniProt ID	[Q9Y5S4](https://www.uniprot.org/uniprot/Q9Y5S4)
Ensembl ID	ENSG00000075643
GeneCards	UNC13B
Human Protein Atlas	UNC13B
Munc13-2 (full-length)	Contains all domains including the C1 domain, allowing phorbol ester-responsive regulation
Munc13-2B	Lacks the C1 domain, resulting in reduced activity-dependent modulation
Munc13-2C	Contains alternative C-terminus with potentially different interaction partners
Associated Diseases	Epilepsy
KG Connections	4 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

UNC13B — UNC13 Homolog B (Munc13-2)

gene · 2682 words

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Pathway Diagram

graph TD
    UNC13B["UNC13B"]
    TREM2["TREM2"]
    UNC13B -->|"associated with"| TREM2
    OxPC["OxPC"]
    UNC13B -->|"associated with"| OxPC
    microglia["microglia"]
    UNC13B -->|"associated with"| microglia
    neurodegeneration["neurodegeneration"]
    UNC13B -->|"associated with"| neurodegeneration
    UNC13B -->|"expressed in"| TREM2
    UNC13B -->|"implicated in"| neurodegeneration
    style UNC13B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (4)

Target	Relation	Type	Str
TREM2	associated_with	gene	0.80
OxPC	associated_with	chemical	0.80
microglia	associated_with	cell_type	0.80
TREM2	expressed_in	gene	0.70

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning UNC13B in their description or question text

No additional research found