Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Trem2-Apoe: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| dysfunctional microglia | drives | phenotype | 0.95 |
| transcriptional phenotype | drives | process | 0.80 |
| microglia | regulates | cell_type | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| TREM2-APOE Axis Dissociation for Selective DAM Activation | 0.886 | neurodegeneration | TREM2 agonism vs antagonism in DAM micro |
| TREM2-APOE microglial state switching across AD, ALS, and PD | 0.804 | multi | Cross-disease neurodegeneration mechanis |
| TREM2-APOE4 Co-targeting — Simultaneous Correction of Lipid | 0.774 | Alzheimer's disease | TREM2 agonism vs antagonism in DAM micro |
| TREM2-APOE4 Axis Drives Metabolic Inflexibility in DAM | 0.708 | Alzheimer's disease | - |
| TREM2-APOE Axis Manipulation via APOE Lipidation for DAM Rec | 0.685 | neurodegeneration | Microglial subtypes in neurodegeneration |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Participants carrying the APOE epsilon 4 allele showed more rapid biom | genetic_association | Alzheimer's disease | 0.500 | 0.00 | human | extracted | N/A |
| Longitudinal plasma biomarker study measuring Aβ42:Aβ40 ratio, p-tau18 | clinical | Alzheimer's disease | 0.500 | 0.00 | human | extracted | N/A |
| APOEε4 carriers showed more rapid biomarker changes (decreasing Aβ42:A | clinical | Alzheimer's disease | 0.500 | 0.00 | human | extracted | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Mic [PMID:28930663] | Krasemann S, Madore C, Cialic R, Baufeld | Immunity | 2017 | 1 |
| Microglial transcriptional profiles of a transgenic rat model closely model Alzh [PMID:41490158] | Finno CJ, Ghosh S, Rodriguez V, Valenzue | J Alzheimers Dis | 2026 | 0 |
| Interpretable machine-learning prediction of PSEN1 missense variant pathogenicit [PMID:41508098] | Yang D, Wang S, Lu Y, Zhu J, Chen J et a | Alzheimers Res Ther | 2026 | 0 |
| Dysregulated Lipid Metabolism and Neurovascular Unit Dysfunction: Novel Mechanis [PMID:41701875] | Li M, Wang H, Tang Z, Yang S, Lin L | Aging Dis | 2026 | 0 |
| TREM2 and microglial immunity in Alzheimer's disease: mechanisms, genetics, and [PMID:41789102] | Wang T, Liu X, Wang X, Hua F, Yan L | Front Immunol | 2026 | 0 |
| The Immuno-Glial Connectome in Alzheimer's Disease: Integrating Central and Peri [PMID:41569436] | Gopalakrishna PK, Che Mohd Nassir CMN, A | Cellular and molecular neurobi | 2026 | 0 |
| Molecular mechanism of Alzheimer's disease using integrated multi-omics. [PMID:41907842] | Alhusaini M, Mussa BM, Ilce BY, Alhaj H, | Frontiers in aging neuroscienc | 2026 | 0 |
| Immuno-Regulation of Brain Region-Specific Organoids Containing Isogenic Microgl [PMID:41408986] | Liu C, Ene J, Lu W, Syed F, Sun L, Rauli | Advanced healthcare materials | 2026 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP- [PMID:34916658] | Xie M, Liu YU, Zhao S, Zhang L, Bosco DB | Nature neuroscience | 2022 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| Multiple Sclerosis Pathology. [PMID:29358320] | Lassmann H | Cold Spring Harbor perspective | 2018 | 0 |
| TREM2 variants in Alzheimer's disease. [PMID:23150934] | Rita Guerreiro, Aleksandra Wojtas, Jose | The New England journal of med | 2013 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning Trem2-Apoe in their description or question text
No additional research found