Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Transglutaminase / protein cross-linking: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| TGM2 | participates_in | gene | 0.41 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Low Complexity Domain Cross-Linking Inhibition | 0.617 | neurodegeneration | TDP-43 phase separation therapeutics for |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.738
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Proposed experiment from debate on TDP-43 undergoes liquid-liquid phas | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| s:** - Dose-response studies showing therapeutic window without toxici | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| Alpha-Synuclein Spreading Mechanism — Prion-Like Propagation and Neuro | exploratory | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $2,070,000 |
| Mechanism: C9orf72 Hexanucleotide Repeat Expansion in ALS/FTD | validation | ALS | 0.400 | 0.50 | human | proposed | $2,730,000 |
| C9orf72 Phenotype Divergence: ALS vs FTD Mechanism Study | clinical | ALS | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Multiscale Computational Modeling of Protein Aggregation Kinetics | validation | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $2,280,000 |
| Prion Strain Diversity and Selective Vulnerability in CJD | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Prion Strain Diversity and Selective Vulnerability | clinical | Alzheimer's Disease | 0.400 | 0.50 | mouse | proposed | $400,000 |
| Proteasome-Ubiquitin System Dysfunction Validation in Parkinson's Dise | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Protein Aggregation Kinetic Validation Results | validation | Neurodegeneration | 0.400 | 0.50 | in_silico | proposed | $120,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Tgm2-Catalyzed Covalent Cross-Linking of IκBα Drives NF-κB Nuclear Translocation [PMID:39749582] | Li Z, Wang T, Du S, Miao Z, Zhao Y, Tang | Aging Cell | 2025 | 1 |
| Role of Serotonylation and SERT Posttranslational Modifications in Alzheimer's D [PMID:39254383] | Reddy AP, Rawat P, Rohr N, Alvir R, Bish | Aging Dis | 2024 | 1 |
| SDC1-dependent TGM2 determines radiosensitivity in glioblastoma by coordinating [PMID:35913916] | Zheng W, Chen Q, Liu H, Zeng L, Zhou Y, | Autophagy | 2023 | 1 |
| How autophagy controls the intestinal epithelial barrier. [PMID:33906557] | Foerster EG, Mukherjee T, Cabral-Fernand | Autophagy | 2022 | 1 |
| TGM2 and implications for human disease: role of alternative splicing. [PMID:23276939] | Lai TS, Greenberg CS | Front Biosci (Landmark Ed) | 2013 | 1 |
| Combining bulk and scRNA-seq to explore the molecular mechanisms governing the d [PMID:38501838] | Zhu S, Cheng Q, Zou M, Li C, Tang Y, Xia | Journal of cellular and molecu | 2024 | 0 |
| The Search for a Universal Treatment for Defined and Mixed Pathology Neurodegene [PMID:39769187] | O'Day DH | International journal of molec | 2024 | 0 |
| Allosteric Activation of Transglutaminase 2 via Inducing an "Open" Conformation [PMID:37088726] | Yang Z, Zhang XW, Zhuo FF, Liu TT, Luo Q | Advanced science (Weinheim, Ba | 2023 | 0 |
| A Consensus-Developed Morphological Re-Evaluation of 196 High-Grade Gastroentero [PMID:33002892] | ["Elvebakken H", "Perren A", "Scoazec J" | Neuroendocrinology | 2021 | 0 |
| Development of Ligand-Drug Conjugates Targeting Melanoma through the Overexpress [PMID:33073191] | ["Zhou Y", "Mowlazadeh Haghighi S", "Liu | ACS pharmacology & translation | 2020 | 0 |
| Dietary Gluten and Neurodegeneration: A Case for Preclinical Studies. [PMID:32751379] | Mohan M, Okeoma CM, Sestak K | International journal of molec | 2020 | 0 |
| Trainee doctor is suspended for 12 months for faking signatures over competencie [PMID:30389657] | Clare Dyer | BMJ (Clinical research ed.) | 2019 | 0 |
| An in vitro model maintaining taxon-specific functional activities of the gut mi [PMID:31515476] | ["Li L", "Abou-Samra E", "Ning Z", "Zhan | Nature communications | 2019 | 0 |
| Human and mouse albumin bind their respective neonatal Fc receptors differently. [PMID:30279529] | ["Nilsen J", "Bern M", "Sand K", "Grevys | Scientific reports | 2018 | 0 |
| Towards frailty biomarkers: Candidates from genes and pathways regulated in agin [PMID:30071357] | Cardoso AL, Fernandes A, Aguilar-Pimente | Ageing research reviews | 2018 | 0 |
| Prevalence and factors associated with age-related macular degeneration in a sou [PMID:29146756] | ["Obata R", "Yanagi Y", "Inoue T", "Yasu | The British journal of ophthal | 2018 | 0 |
| Effect of maternal high dosages of folic acid supplements on neurocognitive deve [PMID:28724645] | ["Valera-Gran D", "Navarrete-Mu\u00f1oz | The American journal of clinic | 2017 | 0 |
| Low Voltage Electrowetting on Ferroelectric PVDF-HFP Insulator with Highly Tunab [PMID:27553685] | ["Sawane Y", "Ogale S", "Banpurkar A"] | ACS applied materials & interf | 2016 | 0 |
| EcR-B1 and Usp nuclear hormone receptors regulate expression of the VM32E eggshe [PMID:19389369] | ["Bernardi F", "Romani P", "Tzertzinis G | Developmental biology | 2009 | 0 |
| Repeated treatment with cannabidiol but not Delta9-tetrahydrocannabinol has a ne [PMID:17320118] | ["Hayakawa K", "Mishima K", "Nozako M", | Neuropharmacology | 2007 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 6 · Score: 0.84 · 2026-04-12
closed · Rounds: 4 · Score: 0.95 · 2026-04-11
Hypotheses and analyses mentioning Transglutaminase / protein cross-linking in their description or question text
No additional research found