gene

TRIM46

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRIM46: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1Connections

0Hypotheses

1Analyses

1Outgoing

0Incoming

0Experiments

1Debates

Summary

Page for TRIM46 Gene

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🧬 Gene Info

Gene Symbol	TRIM46
Chromosome	1q21.3
Protein Type	Gene
Function	is a member of the TRIM (Tripartite Motif) protein family that is predominantly expressed in neurons and plays a critical role in establishing and maintaining neuronal polarity.
Primary Expression	neurons and plays a critical role in establishing and maintaining neuronal polarity
Subcellular Localization	the initial axon segment (AIS), a specialized membrane domain that acts as a gateway for action potential initiation and
Molecular Weight	85 kDa
Amino Acids	750 aa
GeneCards	TRIM46
Human Protein Atlas	TRIM46
Associated Diseases	neurodegeneration
KG Connections	1 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

TRIM46 Gene

gene · 1235 words

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Pathway Diagram

graph TD
    TRIM46["TRIM46"]
    neurodegeneration["neurodegeneration"]
    TRIM46 -->|"implicated_in"| neurodegeneration
    style TRIM46 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1)

Target	Relation	Type	Str
synaptoneurosomes	associated_with	process	0.70

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Do astrocytes functionally express TRIM46, and can PKCα phosphorylate it to driv

molecular biology | 2026-04-13 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The P2X7 hypothesis relies on TRIM46-mediated actin polymerization in astrocytes

closed · Rounds: 4 · Score: 0.95 · 2026-04-16

Related Research

Hypotheses and analyses mentioning TRIM46 in their description or question text

No additional research found