Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TRIM20: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | Tripartite Motif Containing 20 |
| Chromosome | 16p13.3 |
| Function | TRIM20, also known as MEFV (Mediterranean Fever), encodes pyrin, an immunoregulatory protein that belongs to the TRIM family of E3 ubiquitin ligases |
| Primary Expression | various tissues: |
| Gene Type | Protein Coding |
| Pathways | Inflammasome |
| UniProt ID | O15587 |
| NCBI Gene ID | 4212 |
| Ensembl ID | ENSG00000103313 |
| OMIM | 249100 |
| Associated Diseases | Familial Mediterranean Fever |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
TRIM20["TRIM20"]
Familial_Mediterranean_Fever["Familial Mediterranean Fever"]
TRIM20 -->|"associated with"| Familial_Mediterranean_Fever
Inflammasome["Inflammasome"]
TRIM20 -->|"participates_in"| Inflammasome
neurodegeneration["neurodegeneration"]
TRIM20 -->|"implicated in"| neurodegeneration
style TRIM20 fill:#1a237e,stroke:#4fc3f7,color:#4fc3f7| Target | Relation | Type | Str |
|---|---|---|---|
| Familial Mediterranean Fever | associated_with | disease | 0.90 |
| Inflammasome | participates_in | pathway | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning TRIM20 in their description or question text
No additional research found