Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TREM2-DAP12 microglial signaling: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| TREM2 | participates_in | gene | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| TREM2 Conformational Stabilizers for Synaptic Discrimination | 0.685 | neurodegeneration | Synaptic pruning by microglia in early A |
| TREM2-mediated microglial tau clearance enhancement | 0.618 | Alzheimer's Disease | Tau propagation mechanisms and therapeut |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.703
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Meta-analysis of LRP1 C766T polymorphism and Alzheimer's disease susce | exploratory | Alzheimer's disease | 0.950 | 0.00 | human patients | proposed | N/A |
| Endothelial CD2AP knockdown effects on memory in male mice | validation | Alzheimer's disease | 0.900 | 0.00 | male mice | proposed | N/A |
| Network Pharmacology Analysis of Shared AD Targets | exploratory | Alzheimer's disease | 0.850 | 0.00 | Computational network analysis | proposed | N/A |
| MRI Phenotyping Method Concordance in Serbian AD Cohort | clinical | Alzheimer's disease | 0.850 | 0.00 | human patients | proposed | N/A |
| HDAC4 inhibition and NHE6 expression mechanism study | exploratory | Alzheimer's disease | 0.850 | 0.00 | proposed | N/A | |
| Endothelin-1 receptor A antagonist rescue in male CD2AP mice | validation | Alzheimer's disease | 0.850 | 0.00 | male mice | proposed | N/A |
| Neuroimmune modulation and Aβ clearance mechanisms | exploratory | Alzheimer's disease | 0.820 | 0.00 | Microglia and astrocytes | proposed | N/A |
| TREM2 KO amyloid pathology study | validation | Alzheimers Disease | 0.800 | 0.00 | Mouse (5xFAD/TREM2-/-) | completed | N/A |
| TREM2 KO amyloid pathology study | validation | Alzheimers Disease | 0.800 | 0.00 | Mouse (5xFAD/TREM2-/-) | completed | N/A |
| TREM2 KO amyloid pathology study | validation | Alzheimers Disease | 0.800 | 0.00 | Mouse (5xFAD/TREM2-/-) | in_progress | N/A |
| TREM2 KO amyloid pathology study | validation | Alzheimers Disease | 0.800 | 0.00 | Mouse (5xFAD/TREM2-/-) | completed | N/A |
| TREM2 KO amyloid pathology study | validation | Alzheimers Disease | 0.800 | 0.00 | Mouse (5xFAD/TREM2-/-) | completed | N/A |
| CD2AP expression and cognitive decline in AD patients | exploratory | Alzheimer's disease | 0.800 | 0.00 | human patients | proposed | N/A |
| Bioinformatics analysis and hub gene identification | exploratory | Alzheimer's disease | 0.800 | 0.00 | computational analysis of tran | proposed | N/A |
| Competing endogenous RNA (ceRNA) network construction | exploratory | Alzheimer's disease | 0.750 | 0.00 | computational network analysis | proposed | N/A |
| Microglial TREM2 Agonist In Vivo Efficacy | validation | Alzheimer's Disease | 0.450 | 0.50 | mouse | proposed | $360,000 |
| TREM2 Agonist Therapy for Parkinson's Disease — Experimental Design | validation | Parkinson's Disease | 0.450 | 0.50 | mouse | proposed | $280,000 |
| Proposed experiment from debate on Synaptic pruning by microglia in ea | falsification | Alzheimer's Disease | 0.400 | 0.50 | mouse | proposed | $200,000 |
| Tau PET Pattern as Therapeutic Response Predictor in 4R-Tauopathy | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $7,500,000 |
| TREM2 KO amyloid pathology study | validation | Alzheimers Disease | 0.200 | 0.00 | Mouse (5xFAD/TREM2-/-) | in_progress | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. [PMID:37384704] | Zhang T, Xu D, Trefts E, Lv M, Inuzuka H | Science | 2023 | 1 |
| Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Ca [PMID:35642214] | Wang M, Pan W, Xu Y, Zhang J, Wan J, Jia | J Inflamm Res | 2022 | 1 |
| TREM2, microglia, and Alzheimer's disease. [PMID:33516818] | Qin Q, Teng Z, Liu C, Li Q, Yin Y, Tang | Mech Ageing Dev | 2021 | 1 |
| Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2- [PMID:31932797] | Zhou Y, Song WM, Andhey PS, Swain A, Lev | Nat Med | 2020 | 1 |
| Microglia in neurodegeneration. [PMID:30258234] | Hickman S, Izzy S, Sen P, Morsett L, El | Nat Neurosci | 2018 | 1 |
| TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease. [PMID:28802038] | Ulland TK, Song WM, Huang SC, Ulrich JD, | Cell | 2017 | 1 |
| How neuroinflammation contributes to neurodegeneration. [PMID:27540165] | Ransohoff RM | Science | 2016 | 1 |
| Emerging pathological mechanisms of Alzheimer's disease pathogenesis: from neuro [PMID:41858793] | ["Wang R", "Feng Y", "Zhou Z", "Jiang J" | Frontiers in aging neuroscienc | 2026 | 0 |
| Increased plasma soluble TREM2 levels in non-Alzheimer's dementia. [PMID:41920402] | Güven Gamze; Gezegen Haşim; & | Acta neurologica Belgica | 2026 | 0 |
| PLCG2 signaling and genetic resilience in Alzheimer's disease. [PMID:41888907] | Tsai AP, Martin AK, Mi A, Yeh AE, Ramire | Molecular neurodegeneration | 2026 | 0 |
| AI-guided design of cyclic peptide binders targeting TREM2 using CycleRFdiffusio [PMID:41435973] | Cho S, Zhu R, Kuncewicz K, Duan H, Gabr | Bioorg Med Chem Lett | 2026 | 0 |
| ITAM-Syk signaling mediates the rebound phenomenon after anti-RANKL antibody dis [PMID:41490759] | Ishizu H, Hasegawa T, Shimizu T, Yamamot | Bone | 2026 | 0 |
| Loss of Triggering Receptor Expressed on Myeloid Cells 2 Impairs Microglial Func [PMID:41643896] | Chen G, Wang Z, Zhao C, Wang C, Li Y et | Am J Pathol | 2026 | 0 |
| Microglial metabolic reprogramming in Alzheimer's disease: Pathways, mechanisms, [PMID:41651180] | Yang FG, Yang H, Han SW, Wang JT, Gao W | Ageing Res Rev | 2026 | 0 |
| Plant-derived bioactive compounds modulate the gut microbiota in Alzheimer's dis [PMID:41678917] | Xue D, Hu X, Li R, Sun T, Qian S et al. | Phytomedicine | 2026 | 0 |
| PLCG2 signaling and genetic resilience in Alzheimer's disease. [PMID:41888907] | Tsai AP, Martin AK, Mi A, Yeh AE, Ramire | Mol Neurodegener | 2026 | 0 |
| TREM2 deficiency delays postnatal microglial maturation and synaptic pruning, le [PMID:41930604] | Yang HC, Deng YS, Zhang J, Zhang T, Song | J Alzheimers Dis | 2026 | 0 |
| Population-scale burden analysis of rare damaging coding variants identifies nov [PMID:41867223] | Le Guen Y, Peña-Tauber A, Pulgrossi RC, | medRxiv : the preprint server | 2026 | 0 |
| Alzheimer's Disease as a Disorder of Neuroimmune Dysregulation. [PMID:41745721] | Aranda-Abreu GE, Rojas-Durán F, Hernánde | Neurology international | 2026 | 0 |
| Serum miRNA-155 and TREM2 as Non-Invasive Biomarkers for Monitoring Neuroinflamm [PMID:41609966] | Nikanfar M, Yousefi H, Nourazarian A | Molecular neurobiology | 2026 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning TREM2-DAP12 microglial signaling in their description or question text
No additional research found