gene

TLR5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TLR5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Hypotheses

0Analyses

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0Experiments

0Debates

Summary

Page for TLR5 Gene

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🧬 Gene Info

Gene Symbol	TLR5
Full Name	Toll-Like Receptor 5
Chromosome	1q41
Protein Type	Receptor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	various immune cells and tissues throughout the body
Molecular Weight	97 kDa
Amino Acids	200 aa
Pathways	MAPK
UniProt ID	[Q9R279](https://www.uniprot.org/uniprot/Q9R279)
Ensembl ID	ENSG00000135831
OMIM	603030
GeneCards	TLR5
Human Protein Atlas	TLR5
Leucine-rich repeat (LRR) domain	The extracellular portion consists of 23 LRR motifs that form a solenoid structure responsible for flagellin recognition
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TLR5["TLR5"]
    Inflammatory_cytokines["Inflammatory cytokines"]
    TLR5 -->|"activates"| Inflammatory_cytokines
    PPAR_alpha["PPAR-alpha"]
    TLR5 -->|"regulates"| PPAR_alpha
    PPAR_gamma["PPAR-gamma"]
    TLR5 -->|"regulates"| PPAR_gamma
    Inflammation["Inflammation"]
    TLR5 -->|"contributes to"| Inflammation
    neurodegeneration["neurodegeneration"]
    TLR5 -->|"implicated in"| neurodegeneration
    Flagellin["Flagellin"]
    Flagellin -->|"binds"| TLR5
    Desulfovibrio_vulgaris["Desulfovibrio vulgaris"]
    Desulfovibrio_vulgaris -->|"interacts with"| TLR5
    style TLR5 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TLR5 in their description or question text

No additional research found