protein

TGM6PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TGM6PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🔬 Protein Info

Gene Symbol	TGM6PROTEIN
Function	is a protein encoded by the TGM6 gene.
Subcellular Localization	** \| Cytoplasm, cell surface, extracellular \|
Molecular Weight	79 kDa
GeneCards	TGM6PROTEIN
Human Protein Atlas	TGM6PROTEIN
Calcium (Ca²⁺)	Binding of calcium ions (multiple sites) induces a conformational change from the compact/closed (inactive) to the extended/open (active) form, exposing the catalytic site
GTP/GDP	Binding of GTP/GDP stabilizes the compact inactive conformation, opposing calcium activation (allosteric regulation)
Reducing conditions	The active-site cysteine must be in the reduced (thiol) form
Closed/compact form	GTP/GDP-bound; catalytically inactive; β-barrel domains packed against the catalytic core, blocking substrate access
Open/extended form	Ca²⁺-bound; catalytically active; β-barrels swing away from the core, exposing the active site and substrate-binding groove
Cytoskeletal proteins	Tubulin, actin, neurofilaments; cross-linking stabilizes the neuronal cytoskeleton
Myelin basic protein (MBP)	Cross-linking by TG6 in oligodendrocytes may stabilize myelin sheaths
[Tau](/proteins/tau)	Tau protein is a substrate for transglutaminase-mediated cross-linking; cross-linked tau is resistant to proteolytic degradation and may contribute to tangle formation
Alpha-synuclein	α-Synuclein cross-linking promotes oligomerization and may accelerate Lewy body pathology
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Transglutaminase 6 Protein

protein · 1152 words

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Pathway Diagram

graph TD
    TGM6PROTEIN["TGM6PROTEIN"]
    neurodegeneration["neurodegeneration"]
    TGM6PROTEIN -->|"implicated_in"| neurodegeneration
    style TGM6PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning TGM6PROTEIN in their description or question text

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