Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TDP-43 RNA processing / phase separation: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| TARDBP | participates_in | gene | 0.42 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Cross-Seeding Prevention Strategy | 0.689 | neurodegeneration | RNA binding protein dysregulation across |
| Glycine-Rich Domain Competitive Inhibition | 0.640 | neurodegeneration | TDP-43 phase separation therapeutics for |
| TDP-43 Cryptic Exon–Targeted ASOs to Restore Hippocampal Gam | 0.577 | neurodegeneration | RNA binding protein dysregulation across |
| Cryptic Exon Silencing Restoration | 0.531 | neurodegeneration | RNA binding protein dysregulation across |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.738
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| TDP-43 mutant mouse model cGAS/STING pathway analysis | validation | amyotrophic lateral sclerosis | 0.900 | 0.00 | TDP-43 mutant mice | proposed | N/A |
| TDP-43 mitochondrial invasion and DNA release via mPTP | exploratory | amyotrophic lateral sclerosis | 0.900 | 0.00 | cultured cells | proposed | N/A |
| TDP-43 mitochondrial invasion and mtDNA release in iPSC motor neurons | exploratory | Amyotrophic Lateral Sclerosis | 0.900 | 0.00 | iPSC-derived motor neurons | proposed | N/A |
| cGAS/STING pathway validation in TDP-43 mutant mice | validation | Amyotrophic Lateral Sclerosis | 0.850 | 0.00 | TDP-43 mutant mice | proposed | N/A |
| cGAMP biomarker analysis in ALS patient spinal cord samples | exploratory | Amyotrophic Lateral Sclerosis | 0.800 | 0.00 | Human ALS patient spinal cord | proposed | N/A |
| TDP-43 pathology prevalence and distribution in AD cases | exploratory | Alzheimer's disease | 0.800 | 0.00 | human postmortem brain tissue | proposed | N/A |
| Cognitive impact of TDP-43 pathology in AD patients | clinical | Alzheimer's disease | 0.700 | 0.00 | human patients | completed | N/A |
| Proposed experiment from debate on TDP-43 undergoes liquid-liquid phas | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| s:** - Single-cell RNA-seq to measure editing efficiency across differ | falsification | ALS | 0.400 | 0.50 | cell_line | proposed | $150,000 |
| Alpha-Synuclein SAA Kinetics Study — Biological Staging Backbone for P | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| ALS Progression Rate Heterogeneity — mechanism and biomarker predictor | clinical | ALS | 0.400 | 0.50 | human | proposed | $6,550,000 |
| s:** - Temporal analysis showing mitochondrial defects precede other p | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $80,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Autophagy and ALS: mechanistic insights and therapeutic implications. [PMID:34057020] | Chua JP, De Calbiac H, Kabashi E, Barmad | Autophagy | 2022 | 2 |
| TDP-43 Pathology in Alzheimer's Disease. [PMID:34930382] | Meneses A, Koga S, O'Leary J, Dickson DW | Mol Neurodegener | 2021 | 2 |
| Protein transmission in neurodegenerative disease. [PMID:32203399] | Peng C, Trojanowski JQ, Lee VM | Nat Rev Neurol | 2020 | 2 |
| TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS [PMID:33031745] | Yu CH, Davidson S, Harapas CR, Hilton JB | Cell | 2020 | 2 |
| Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of [PMID:30335591] | Rusmini P, Cortese K, Crippa V, Cristofa | Autophagy | 2019 | 2 |
| Targets and Gene Therapy of ALS (Part 1). [PMID:40362304] | Shiryaeva O, Tolochko C, Alekseeva T, Dy | Int J Mol Sci | 2025 | 1 |
| The genetics of amyotrophic lateral sclerosis. [PMID:38967083] | Nijs M, Van Damme P | Curr Opin Neurol | 2024 | 1 |
| TDP-43 regulates LC3ylation in neural tissue through ATG4B cryptic splicing inhi [PMID:39305312] | Torres P, Rico-Rios S, Ceron-Codorniu M, | Acta Neuropathol | 2024 | 1 |
| N protein of PEDV plays chess game with host proteins by selective autophagy. [PMID:36861818] | Zhai X, Kong N, Zhang Y, Song Y, Qin W, | Autophagy | 2023 | 1 |
| PIKFYVE inhibition mitigates disease in models of diverse forms of ALS. [PMID:36754049] | Hung ST, Linares GR, Chang WH, Eoh Y, Kr | Cell | 2023 | 1 |
| TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A. [PMID:35197628] | Brown AL, Wilkins OG, Keuss MJ, Kargbo-H | Nature | 2022 | 1 |
| Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP- [PMID:28405022] | Becker LA, Huang B, Bieri G, Ma R, Knowl | Nature | 2017 | 1 |
| Selective Silencing of TDP-43 P. G376D Mutation Reverses Key Amyotrophic Lateral [PMID:41897327] | Romano R, Ruotolo G, Perrone F, Tomasell | Biomolecules | 2026 | 0 |
| ALS-related proteinopathies: From TDP-43 to mitochondrial proteinopathies. [PMID:41570741] | Genin EC, Paquis-Flucklinger V | Current opinion in neurobiolog | 2026 | 0 |
| Chemical and Molecular Strategies in Restoring Autophagic Flux in TDP-43 Protein [PMID:41900026] | Jamerlan A, Hulme J | Molecules (Basel, Switzerland) | 2026 | 0 |
| Axonal transport impairment as an upstream mechanism in amyotrophic lateral scle [PMID:41890591] | Gabbay U | Frontiers in neuroscience | 2026 | 0 |
| Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA- [PMID:41512823] | ["Guo L", "Mann J", "Mauna J", "Copley K | Molecular cell | 2026 | 0 |
| Role of Alpha-Synuclein in Frontotemporal Dementia: Narrative Review. [PMID:41827903] | Bougea A | Cells | 2026 | 0 |
| Versatile CRISPR-Cas Tools for Gene Regulation in Zebrafish via an Enhanced Q Bi [PMID:41671402] | ["Shi M", "Ge W", "Li C", "Liu B", "Deng | Advanced science (Weinheim, Ba | 2026 | 0 |
| Splicing the narrative: alternative TARDBP splicing and its relation to neurodeg [PMID:41837283] | Miller MR, Dykstra M, Barmada S | The Journal of clinical invest | 2026 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 6 · Score: 0.84 · 2026-04-12
closed · Rounds: 4 · Score: 0.95 · 2026-04-11
Hypotheses and analyses mentioning TDP-43 RNA processing / phase separation in their description or question text
No additional research found