concept

TDP-43 MISLOCALIZATION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TDP-43 MISLOCALIZATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

18Connections

3Hypotheses

4Analyses

7Outgoing

11Incoming

0Experiments

7Debates

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💡 Concept Info

Name	TDP-43 MISLOCALIZATION

Pathway Diagram

graph TD
    TDP_43_MISLOCALIZATION[TDP-43 MISLOCALIZATION]
    TDP_43_MISLOCALIZATION -->|causes| aberrant_splicing[aberrant splicing]
    TDP_43_MISLOCALIZATION -.biomarker for.-> Amyotrophic_Lateral_Sclerosis[Amyotrophic Lateral Sclerosis]
    TDP_43_MISLOCALIZATION -->|activates| DNA_damage[DNA damage]
    TDP_43_MISLOCALIZATION -->|regulates| splicing_regulation[splicing regulation]
    cAMP_PKA_Signaling[cAMP/PKA Signaling] -->|modulates| TDP_43_MISLOCALIZATION
    TARDBP[TARDBP] -->|involved_in| TDP_43_MISLOCALIZATION
    NUP107_Depletion[NUP107 Depletion] -->|causes| TDP_43_MISLOCALIZATION
    UBQLN2_P497H[UBQLN2 P497H] -->|causes| TDP_43_MISLOCALIZATION
    TDP_43_Aggregation[TDP-43 Aggregation] -->|interacts| TDP_43_MISLOCALIZATION
    SRRM2[SRRM2] -->|modulates| TDP_43_MISLOCALIZATION
    Nuclear_Speckle_Integrity[Nuclear Speckle Integrity] -->|mediates| TDP_43_MISLOCALIZATION
    UBQLN2_mutation[UBQLN2 mutation] -->|causes| TDP_43_MISLOCALIZATION

Outgoing (7)

Target	Relation	Type	Str
Amyotrophic Lateral Sclerosis	associated_with	disease	0.98
STMN2 depletion	causes	phenotype	0.90
Neuronal Inclusions	causes	phenotype	0.90
Amyotrophic Lateral Sclerosis	biomarker_for	disease	0.90
aberrant splicing	causes	process	0.90
DNA damage	activates	process	0.70
splicing regulation	regulates	process	0.70

Incoming (11)

Source	Relation	Type	Str
cAMP/PKA Signaling	modulates	pathway	0.95
TARDBP	involved_in	protein	0.90
NUP107 Depletion	causes	mechanism	0.90
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.90
UBQLN2 P497H	causes	protein	0.85
TDP-43 Aggregation	interacts_with	process	0.85
SRRM2	modulates	gene	0.80
Nuclear Speckle Integrity	mediates	mechanism	0.80
UBQLN2 mutation	causes	gene	0.80
DPR proteins	causes	protein	0.70
neuroinflammation	causes	process	0.50

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TIA1 Low-Complexity Domain Oxidation Drives Aberrant Stress	0.810	ALS	-
Neuroinflammation-Driven TDP-43 Mislocalization via Microgli	0.580	neurodegeneration	How does APOE4 mechanistically increase
SASP-Secreted MMP-9 from Senescent Microglia Disrupts Nuclea	0.361	ALS	What are the mechanisms by which microgl