Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Synaptic adhesion: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| catecholamine regulation | regulates | pathway | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Trans-Synaptic Adhesion Molecule Modulation | 0.544 | Alzheimer's Disease | Tau propagation mechanisms and therapeut |
| Trans-Synaptic Adhesion Molecule Modulation | 0.503 | neurodegeneration | Tau propagation mechanisms and therapeut |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Spp1 knockout prevents synaptic loss in AD mouse models | validation | Alzheimer's disease | 0.900 | 0.00 | Spp1 knockout AD mouse models | proposed | N/A |
| Adoptive transfer of TCRAβ-Tregs in AD mouse model | validation | Alzheimer's disease | 0.900 | 0.00 | transgenic mice expressing chi | proposed | N/A |
| AhR transcriptional regulation of NEP gene | exploratory | Alzheimer's disease | 0.850 | 0.00 | Cell culture system | proposed | N/A |
| Bioinformatics analysis and hub gene identification | exploratory | Alzheimer's disease | 0.800 | 0.00 | computational analysis of tran | proposed | N/A |
| Synaptic Vesicle Trafficking Dysfunction Validation in Parkinson's Dis | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $7,500,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| NRXN3-NLGN1 complex influences the development of depression induced by maternal [PMID:40286836] | Rong Y, Yan W, Gao Z, Yang Y, Xu C, Zhan | Brain research | 2025 | 0 |
| Membrane trafficking of synaptic adhesion molecules. [PMID:39322997] | ["Bogaciu C", "Rizzoli S"] | The Journal of physiology | 2025 | 0 |
| Activation of hypothalamic-pontine-spinal pathway promotes locomotor initiation [PMID:41353490] | ["Ji C", "Zhang Y", "Lin Z", "Zhao Z", " | Nature communications | 2025 | 0 |
| Molecular Signatures of Resilience to Alzheimer's Disease in Neocortical Layer 4 [PMID:39574639] | Dharshini SAP, Sanz-Ros J, Pan J, Tang W | bioRxiv : the preprint server | 2024 | 0 |
| Cross-disorder and disease-specific pathways in dementia revealed by single-cell [PMID:39265576] | Rexach JE, Cheng Y, Chen L, Polioudakis | Cell | 2024 | 0 |
| Organizing the synaptic junctions. [PMID:37060998] | ["Zhou Q"] | The Journal of biological chem | 2023 | 0 |
| A Neuroligin-1 mutation associated with Alzheimer's disease produces memory and [PMID:37260747] | Arias-Aragón F, Tristán-Clavijo E, Martí | iScience | 2023 | 0 |
| Reelin through the years: From brain development to inflammation. [PMID:37339050] | Alexander A, Herz J, Calvier L | Cell reports | 2023 | 0 |
| Molecular mechanisms of synaptogenesis. [PMID:36176941] | ["Qi C", "Luo L", "Feng I", "Ma S"] | Frontiers in synaptic neurosci | 2022 | 0 |
| In vivo nanoscopic landscape of neurexin ligands underlying anterograde synapse [PMID:36007521] | Nozawa K, Sogabe T, Hayashi A, Motohashi | Neuron | 2022 | 0 |
| Neuroligin-1 in brain and CSF of neurodegenerative disorders: investigation for [PMID:33522967] | Camporesi E, Lashley T, Gobom J, Lantero | Acta neuropathologica communic | 2021 | 0 |
| PSD-95 binding dynamically regulates NLGN1 trafficking and function. [PMID:31138690] | Jeong J, Pandey S, Li Y, Badger JD, Lu W | Proceedings of the National Ac | 2019 | 0 |
| NLGN1 and NLGN2 in the prefrontal cortex: their role in memory consolidation and [PMID:29278843] | Katzman A, Alberini CM | Current opinion in neurobiolog | 2018 | 0 |
| Declining levels of functionally specialized synaptic proteins in plasma neurona [PMID:29025866] | Goetzl EJ, Abner EL, Jicha GA, Kapogiann | FASEB journal : official publi | 2018 | 0 |
| Structural Insights into Modulation of Neurexin-Neuroligin Trans-synaptic Adhesi [PMID:28641111] | ["Kim J", "Kim D", "Won S", "Han K", "Pa | Neuron | 2017 | 0 |
| Role of Neurexin-1β and Neuroligin-1 in Cognitive Dysfunction After Subarachnoid [PMID:26219651] | ["Shen H", "Chen Z", "Wang Y", "Gao A", | Stroke | 2015 | 0 |
| Evidence for Association of Cell Adhesion Molecules Pathway and NLGN1 Polymorphi [PMID:26674772] | Zhang Z, Yu H, Jiang S, Liao J, Lu T, Wa | PloS one | 2015 | 0 |
| Neurexins. [PMID:24083347] | ["Reissner C", "Runkel F", "Missler M"] | Genome biology | 2013 | 0 |
| Genetic study of neurexin and neuroligin genes in Alzheimer's disease. [PMID:23403532] | Martinez-Mir A, González-Pérez A, Gayán | Journal of Alzheimer's disease | 2013 | 0 |
| Overexpression of the cell adhesion protein neuroligin-1 induces learning defici [PMID:19437420] | ["Dahlhaus R", "Hines R", "Eadie B", "Ka | Hippocampus | 2010 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning Synaptic adhesion in their description or question text
No additional research found