Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Substrates: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| Autophagy Receptors | targets | protein | 0.95 |
| P25 | phosphorylates | protein | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| VCP/p97 ATPase mutations impair extraction of ubiquitinated | 0.720 | neurodegeneration | What are the neuron-specific effects of |
| Microglial TREM2 state determines whether C1q-tagged substra | 0.670 | neurodegeneration | Does C1q function differ based on subcel |
| USP14 Inhibition to Accelerate Proteasomal Degradation of Sy | 0.486 | proteomics | Quantitative proteomics of the aging syn |
| Differential Calpain-Mediated Cleavage of Apoptotic vs. Auto | 0.420 | neurodegeneration | How does controlled lysosomal membrane p |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning Substrates in their description or question text
No additional research found