Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Stress granule / RNA granule assembly: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| G3BP1 | participates_in | gene | 0.46 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Phase-Separated Organelle Targeting | 0.729 | neurodegeneration | Microglia-astrocyte crosstalk amplificat |
| Stress Granule Phase Separation Modulators | 0.720 | neurodegeneration | RNA binding protein dysregulation across |
| RNA Granule Nucleation Site Modulation | 0.662 | neurodegeneration | TDP-43 phase separation therapeutics for |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.738
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| G3BP1-mediated stress granule assembly via liquid-liquid phase separat | exploratory | 0.900 | 0.00 | eukaryotic cells | proposed | N/A | |
| G3BP1 intrinsically disordered region analysis and phosphorylation eff | exploratory | 0.850 | 0.00 | in vitro protein analysis syst | proposed | N/A | |
| G3BP1-binding factor cooperativity in stress granule network regulatio | exploratory | 0.800 | 0.00 | cell culture systems with prot | proposed | N/A | |
| Proposed experiment from debate on TDP-43 undergoes liquid-liquid phas | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| Mechanism: C9orf72 Hexanucleotide Repeat Expansion in ALS/FTD | validation | ALS | 0.400 | 0.50 | human | proposed | $2,730,000 |
| C9orf72 Phenotype Divergence: ALS vs FTD Mechanism Study | clinical | ALS | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Pre-Symptomatic Detection and Intervention Timing in Genetic Prion Dis | validation | ALS | 0.400 | 0.50 | human | proposed | $2,280,000 |
| Stress Granule Dysfunction Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Experiment Validation: In vitro ThT Assay | validation | Alzheimer's Disease | 0.400 | 0.50 | cell_line | proposed | $160,000 |
| Mutant Huntingtin (mHTT) Clearance Mechanisms — Therapeutic Target Val | validation | Neurodegeneration | 0.400 | 0.50 | human | proposed | $3,000,000 |
| Multiscale Computational Modeling of Protein Aggregation Kinetics | validation | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $2,280,000 |
| Protein Aggregation Kinetic Validation Results | validation | Neurodegeneration | 0.400 | 0.50 | in_silico | proposed | $120,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Stress granule homeostasis is modulated by TRIM21-mediated ubiquitination of G3B [PMID:36692217] | Yang C, Wang Z, Kang Y, Yi Q, Wang T, Ba | Autophagy | 2023 | 3 |
| G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Gran [PMID:32302571] | Yang P, Mathieu C, Kolaitis RM, Zhang P, | Cell | 2020 | 3 |
| Organelle-specific autophagy in inflammatory diseases: a potential therapeutic t [PMID:32048886] | Yao RQ, Ren C, Xia ZF, Yao YM | Autophagy | 2021 | 2 |
| Hypoxia-driven phase separation of the PABP1/eIF4B complex forms stress granules [PMID:41780839] | Lin Z, Gao Y, Zhang Q, Yang S, Chen Y, D | Cancer Lett | 2026 | 1 |
| LINC00599 Promotes Pulmonary Hypertension via Liquid-Liquid Phase Separation Wit [PMID:40693377] | Wang Y, Yin L, Zheng S, Liu A, Liu C, Ba | Hypertension | 2025 | 1 |
| The important role of stress granules in prostate cancer development, progressio [PMID:40972860] | Xu Z, You H, Gu J, Jiang J, Yan Z, Jin X | Gene | 2025 | 1 |
| Membrane Atg8ylation, stress granule formation, and MTOR regulation during lysos [PMID:36394332] | Jia J, Wang F, Bhujabal Z, Peters R, Mud | Autophagy | 2023 | 1 |
| Role of stress granules in modulating senescence and promoting cancer progressio [PMID:34460104] | Chatterjee D, Chakrabarti O | Int J Cancer | 2022 | 1 |
| Ubiquitination of G3BP1 mediates stress granule disassembly in a context-specifi [PMID:34739333] | Gwon Y, Maxwell BA, Kolaitis RM, Zhang P | Science | 2021 | 1 |
| STING is the scaffold protein for stress granule pre-condensation at the ER. [PMID:41917183] | Eom E, Kim J, Kim J, Kang SJ | Cell death and differentiation | 2026 | 0 |
| Stress granules: Guardians of cellular health and triggers of disease. [PMID:39995077] | ["Desai M", "Gulati K", "Agrawal M", "Gh | Neural regeneration research | 2026 | 0 |
| WFDC21P is essential for G3BP1-mediated RIG-I activation and antitumor immunity [PMID:41915747] | Li Z, Wang Y, Chen Z, Liu R, Lai ZH, Li | Proceedings of the National Ac | 2026 | 0 |
| NUP93 facilitates the nuclear import of SOX2 to activate G3BP1 transcription and [PMID:41896201] | Sun H, Yang C, Du J, Xu C, Chen Y, Chen | Cell death & disease | 2026 | 0 |
| Implications of virus-induced stress granules in tauopathies. [PMID:41673769] | Sharma S, Vandenakker A, Cortés-Pérez C, | Translational neurodegeneratio | 2026 | 0 |
| Evolution of a truncated nucleocapsid protein enhances SARS-CoV-2 fitness by sup [PMID:41920932] | Mulloy RP, Evseev D, Sharlin N, Bui-Mari | PLoS biology | 2026 | 0 |
| PRRC2A, PRRC2B and PRRC2C are Stress Granule Proteins that Promote Translation T [PMID:41808986] | ["Huang J", "Kadijk E", "Schreiber K", " | bioRxiv : the preprint server | 2026 | 0 |
| Rainbow trout (Oncorhynchus mykiss) G3BP1 function as an antiviral molecule agai [PMID:41831384] | ["Zhao J", "Shao Y", "Liu W", "Lu T", "X | Fish & shellfish immunology | 2026 | 0 |
| Stress granules: Guardians of cellular health and triggers of disease. [PMID:39995077] | Desai M, Gulati K, Agrawal M, Ghumra S, | Neural Regen Res | 2026 | 0 |
| Implications of virus-induced stress granules in tauopathies. [PMID:41673769] | Sharma S, Vandenakker A, Cortés-Pérez C, | Transl Neurodegener | 2026 | 0 |
| Pharmacological modulation of stress granules via G3BP1/2: A pathway to treat ca [PMID:41924133] | Yang J, Gao F | Front Pharmacol | 2026 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 6 · Score: 0.84 · 2026-04-12
closed · Rounds: 4 · Score: 0.95 · 2026-04-11
Hypotheses and analyses mentioning Stress granule / RNA granule assembly in their description or question text
No additional research found