Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Skin: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Corticosterone | expressed_in | compound | 0.75 |
| IL6 | expresses | protein | 0.72 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics | 0.680 | neurodegeneration | Synaptic pruning by microglia in early A |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Basic Mechanism: Membrane-Driven Alpha-Synuclein Nucleation | validation | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $2,730,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Loss of Annexin A1 in macrophages restrains efferocytosis and remodels immune mi [PMID:39237260] | Hou Z, Lu F, Lin J, Wu Y, Chen L, Fang H | J Immunother Cancer | 2024 | 1 |
| The role of annexins in central nervous system development and disease. [PMID:38639785] | White ZB 2nd, Nair S, Bredel M | J Mol Med (Berl) | 2024 | 1 |
| Tat-NTS peptide protects neurons against cerebral ischemia-reperfusion injury vi [PMID:37908731] | Zhou H, Yan L, Huang H, Li X, Xia Q, Zhe | Theranostics | 2023 | 1 |
| Annexin A1 protects against cerebral ischemia-reperfusion injury by modulating m [PMID:34022892] | Xu X, Gao W, Li L, Hao J, Yang B, Wang T | J Neuroinflammation | 2021 | 1 |
| Annexin A1: Uncovering the Many Talents of an Old Protein. [PMID:29614751] | Sheikh MH, Solito E | Int J Mol Sci | 2018 | 1 |
| LINC00491 promotes nasopharyngeal carcinoma metastasis by binding to purine-rich [PMID:41903631] | ["Liu Y", "Li H", "Zhang J", "Peng J", " | International journal of biolo | 2026 | 0 |
| GW201 mediates neuroprotection via allosteric modulation of NMDA receptor activi [PMID:41693050] | ["Tiliwaerde M", "Zhaoji D", "Jingjing L | British journal of pharmacolog | 2026 | 0 |
| Annexin A1 enhances liver repair after acetaminophen-induced liver injury by reg [PMID:41707743] | ["Zha L", "Liu D", "Zhan M", "Xu Y", "Ha | Free radical biology & medicin | 2026 | 0 |
| Myeloid cell-specific β2-adrenergic receptor deletion improves early cardiac inj [PMID:41695468] | ["Nayak T", "Bajpai A", "Patwa V", "Cart | Theranostics | 2026 | 0 |
| Sex-specific hypothalamic PVN transcriptomic signatures of blood pressure autono [PMID:41723507] | ["Duque V", "Nani J", "Jovanovic M", "Lo | Biology of sex differences | 2026 | 0 |
| Attenuated crosstalk between urothelium and fibroblasts promotes ureteral strict [PMID:41924262] | ["Guo R", "Zhang X", "Wang C", "Cui J", | Frontiers in immunology | 2026 | 0 |
| AnnexinA1-Dectin 1 axis is a key regulator of osteoclastogenesis underlying irra [PMID:41925240] | ["Guliyeva G", "Takile F", "Stallfort V" | Journal of bone and mineral re | 2026 | 0 |
| Characterization of ANXA1 in chemotherapy resistance of head and neck squamous c [PMID:41836290] | ["Zheng L", "Yang H", "Cheng Y", "Xia B" | Frontiers in cell and developm | 2026 | 0 |
| The invasion phenotypes of glioblastoma depend on plastic and reprogrammable cel [PMID:40683881] | ["Doroszko M", "Stockgard R", "Uppman I" | Nature communications | 2025 | 0 |
| Loss of Endothelial Annexin A1 Aggravates Inflammation-Induched Vascular Aging. [PMID:38358087] | You Q, Ke Y, Chen X, Yan W, Li D, Chen L | Advanced science (Weinheim, Ba | 2024 | 0 |
| Anxa1 in smooth muscle cells protects against acute aortic dissection. [PMID:33757117] | Zhou C, Lin Z, Cao H, Chen Y, Li J, Zhua | Cardiovascular research | 2022 | 0 |
| Immunogenic Cell Death by the Novel Topoisomerase I Inhibitor TLC388 Enhances th [PMID:33799527] | ["Huang K", "Chiang S", "Yang P", "Ke T" | Cancers | 2021 | 0 |
| Identification of AnnexinA1 as an Endogenous Regulator of RhoA, and Its Role in [PMID:30972066] | ["Purvis G", "Collino M", "Loiola R", "B | Frontiers in immunology | 2019 | 0 |
| Annexin A1-derived peptide Ac [PMID:30755225] | ["Gimenes A", "Andrade B", "Pinotti J", | Journal of neuroinflammation | 2019 | 0 |
| Annexins-Coordinators of Cholesterol Homeostasis in Endocytic Pathways. [PMID:29757220] | Rentero C, Blanco-Muñoz P, Meneses-Salas | International journal of molec | 2018 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning Skin in their description or question text
No additional research found