Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Sirtuin-1 / NAD+ metabolism / deacetylation: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| SIRT1 | participates_in | gene | 0.62 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Metabolic Reprogramming to Reverse Senescence | 1.000 | - | Senescent cell clearance as neurodegener |
| Nutrient-Sensing Epigenetic Circuit Reactivation | 0.907 | neurodegeneration | Epigenetic reprogramming in aging neuron |
| Epigenetic Memory Reprogramming via CRISPRa-Mediated Chromat | 0.690 | neurodegeneration | CRISPR-based therapeutic approaches for |
| Astrocyte Metabolic Memory Reprogramming | 0.646 | neurodegeneration | How do astrocyte-neuron metabolic intera |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 9 hypotheses Top: 0.914
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Gandouling protection against brain injury in Wilson's disease via SIR | validation | Hepatolenticular degeneration | 0.900 | 0.00 | TX mice (Wilson's disease mode | proposed | N/A |
| Acteoside treatment in LPS-induced SALI mouse model | validation | sepsis-associated acute lung i | 0.900 | 0.00 | LPS-induced SALI mouse model | proposed | N/A |
| Nrf2 inhibitor ML385 mechanism validation experiment | exploratory | sepsis-associated acute lung i | 0.850 | 0.00 | RAW264.7 cells and/or mouse mo | proposed | N/A |
| Acteoside effects on RAW264.7 macrophage cells | exploratory | sepsis-associated acute lung i | 0.850 | 0.00 | RAW264.7 cells | proposed | N/A |
| Cognitive Reserve Mechanisms in Alzheimer's Disease — Molecular Basis | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Epigenetic Clocks in Neurodegeneration — Causal Drivers or Passive Mar | validation | Neurodegeneration | 0.400 | 0.50 | human | proposed | $3,000,000 |
| Epigenetic Dysregulation Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $7,500,000 |
| Lifestyle Intervention Mechanisms in Alzheimer's Disease | validation | Alzheimer's Disease | 0.400 | 0.50 | mouse | proposed | $430,000 |
| Normal Aging to Alzheimer's Disease Transition Trigger — Identifying t | validation | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $2,280,000 |
| Sirtuin Dysfunction Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Sirtuin Pathway Dysfunction Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| NAD+ subcellular partitioning mediated by miR-183 and miR-96 regulates muscle st [PMID:41915008] | Ma M, Ma R, Li Z, Shen S, Kong W, Qiu T, | Journal of molecular cell biol | 2026 | 0 |
| Rhodiola sacra Protects Against Hippocampal Neuronal Apoptosis in Chronic Cerebr [PMID:41879438] | Zhou L, Jia J, Li J, Yao Z, Fu Z, Wang S | Current neuropharmacology | 2026 | 0 |
| Mechanistic Modulation of Autophagy by Bioactive Natural Products: Implications [PMID:41830033] | Jalouli M, Harrath AH, Al-Zharani M, Rah | Nutrients | 2026 | 0 |
| Mechanistic advances in exercise‑mediated regulation of autophagy dysfunction in [PMID:41645754] | Li W, Wang WH, Song Y, Li XJ, Li Y et al | Int J Mol Med | 2026 | 0 |
| Integrative SMR prioritizes oxidative stress-related regulatory genes for Alzhei [PMID:41844011] | Wu L, Dong YT, Mu X, Luo X, Chen ZJ | J Prev Alzheimers Dis | 2026 | 0 |
| Insulin resistance and SIRT1 dysregulation in neurodegenerative diseases. [PMID:41759326] | Shah A, Doshi G | Ageing research reviews | 2026 | 0 |
| Urolithin A Reverses Intranigral Rotenone-Generated Parkinsonism by Modulating D [PMID:41880654] | Devi A, Singh SB, Srivastava S, Dandekar | ACS chemical neuroscience | 2026 | 0 |
| Microglial Activation Under Hypoxic Conditions in Early Alzheimer's Disease: Can [PMID:41902653] | Merlo S, Lipari CLR, Patti A, Sortino MA | Phytotherapy research : PTR | 2026 | 0 |
| Subtype-specific sirtuin expression signatures link mitochondrial-epigenetic net [PMID:41692938] | Ungvari Z, Menyhárt O, Ocana A, Lehoczki | GeroScience | 2026 | 0 |
| All the Way: A Decade of SIRT1 in Breast Cancer. [PMID:41898317] | Pratelli G, Montalbano M, Affranchi F, O | Biomedicines | 2026 | 0 |
| Therapeutic potential of sulforaphane in neurodegenerative diseases: mechanistic [PMID:41894075] | Kuwar Omkar Kumar; Tejpal Sandip; Sharma | Molecular biology reports | 2026 | 0 |
| Uncovering the metabolic-epigenetic links between gene expression and stroke: in [PMID:41877258] | Kan J, Hong Y, Min R, Zhang B, Wang H | Neurological research and prac | 2026 | 0 |
| Dysregulation of SIRT1, polyamines and miRNA editing in cancer and aging. [PMID:41863647] | Ramamonjiharisoa MBM, Liu S | Amino acids | 2026 | 0 |
| Immune-metabolic positive feedback model in COPD: cross-mechanisms and potential [PMID:41869013] | Chen W, Huang S, He L, Zhou X, Li R, Wan | Frontiers in cell and developm | 2026 | 0 |
| Unraveling Network Pharmacology-Based Therapeutics of Anthranilate Sulfonamides [PMID:41714304] | Ruankham W, Prachayasittikul V, Pingaew | Journal of neurochemistry | 2026 | 0 |
| Advances and Therapeutic Potential of Anthraquinone Compounds in Neurodegenerati [PMID:41868184] | Liu Z, Zhang H, Wan B, Yin S, Yue R | Drug design, development and t | 2026 | 0 |
| Integrative SMR prioritizes oxidative stress-related regulatory genes for Alzhei [PMID:41844011] | Wu L, Dong YT, Mu X, Luo X, Chen ZJ | The journal of prevention of A | 2026 | 0 |
| AMPK/SIRT1/PGC-1α Signaling Pathway: Molecular Mechanisms and Targeted Strategie [PMID:41268687] | Chen J, Liu B, Yao X, Yang X, Sun J et a | CNS Neurosci Ther | 2025 | 0 |
| Nicotinamide N-methyltransferase as a potential therapeutic target for neurodege [PMID:40221009] | ["Liu A", "Zhu X", "Sun W", "Bi S", "Zha | Experimental neurology | 2025 | 0 |
| PTBP1 Lactylation Promotes Glioma Stem Cell Maintenance through PFKFB4-Driven Gl [PMID:39570804] | Zhou Z, Yin X, Sun H, Lu J, Li Y, Fan Y, | Cancer research | 2025 | 0 |
Multi-agent debates referencing this entity