gene

SURF2

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about SURF2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Gene profile: SURF2

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🧬 Gene Info

Gene Symbol	SURF2
Full Name	SURF2 Homolog
Chromosome	9q34.2
Protein Type	Mitochondrial assembly factor
Function	The SURF complex (comprising SURF1 and SURF2) facilitates the proper insertion of copper ions into the COX1 subunit and stabilizes the assembly intermediates during Complex IV biogenesis[@stiburek2014
NCBI Gene ID	6834
GeneCards	SURF2
Human Protein Atlas	SURF2
Brain	Particularly in the cortex, hippocampus, and cerebellum[@uhln2005]
Heart	High expression due to constant energy requirements
Skeletal muscle	Major consumer of ATP for contraction
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SURF2 — SURF2 Homolog

gene · 737 words

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Pathway Diagram

flowchart TD
    A["Upstream Regulators"] --> B["SURF2"]
    B --> C["Molecular Mechanism"]
    C --> D["Cellular Effects"]
    D --> E["Pathological Consequences"]

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning SURF2 in their description or question text

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