Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SUMF2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Comprehensive review of SUMF2 gene, encoding sulfatase modifying factor 2, a critical cofactor for sulfatase activation with roles in multiple neurodegenerative and metabolic conditions
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| Gene Symbol | SUMF2 |
| Full Name | Sulfatase Modifying Factor 2 |
| Chromosome | 7p11.2 |
| Function | is a human gene located on chromosome 7p11. |
| Primary Expression | Ubiquitous - Brain, Liver, Lung, Heart, Muscle |
| Molecular Weight | 41 kDa |
| Amino Acids | 374 aa |
| UniProt ID | Q8IWA5 |
| NCBI Gene ID | 25873 |
| Ensembl ID | ENSG00000129197 |
| OMIM | 607944 |
| GeneCards | SUMF2 |
| Human Protein Atlas | SUMF2 |
| Consensus sequence | The modification occurs at a specific cysteine within the C(X)PSR motif |
| Catalytic mechanism | FGE oxidizes the cysteine sulfhydryl to an aldehyde (FGly) |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
SUMF2["SUMF2"]
neurodegeneration["neurodegeneration"]
SUMF2 -->|"implicated_in"| neurodegeneration
style SUMF2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning SUMF2 in their description or question text
No additional research found