Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about STUB1 (CHIP), HSPA8, VCP, PSMD4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| CHIP-mediated ubiquitination selectively targets oligomeric | 0.590 | protein biochemistry | Do chaperones selectively recognize path |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Hsp multichaperone complex buffers pathologically modified Tau. [PMID:35760815] | Unknown | Nat Commun | 2022 | 0 |
| Treadmill exercise promotes E3 ubiquitin ligase to remove amyloid β and P-tau an [PMID:36195875] | Unknown | J Neuroinflammation | 2022 | 0 |
| Tau protein degradation is catalyzed by the ATP/ubiquitin-independent 20S protea [PMID:20478262] | Unknown | Arch Biochem Biophys | 2010 | 0 |
| CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation. [PMID:14962978] | Unknown | Hum Mol Genet | 2004 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning STUB1 (CHIP), HSPA8, VCP, PSMD4 in their description or question text
No additional research found