Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about STAB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
STAB1 (Stabilin 1) - scavenger receptor mediating endocytosis, tissue homeostasis, and neuroinflammation in neurodegenerative diseases
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| Gene Symbol | STAB1 |
| Full Name | Stabilin 1 |
| Chromosome | 3p22.1 |
| Protein Type | Receptor |
| Function | is a large transmembrane scavenger receptor expressed predominantly on sinusoidal endothelial cells, macrophages, and certain populations of microglia in the brain. |
| Amino Acids | 550 aa |
| UniProt ID | Q9Y5K6 |
| NCBI Gene ID | 23168 |
| Ensembl ID | ENSG00000010318 |
| OMIM | 608744 |
| GeneCards | STAB1 |
| Human Protein Atlas | STAB1 |
| N-linked glycosylation | Multiple sites in extracellular domains |
| Tyrosine sulfation | In the extracellular region |
| Palmitoylation | Potential at cysteine residues |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
STAB1["STAB1"]
neurodegeneration["neurodegeneration"]
STAB1 -->|"implicated_in"| neurodegeneration
style STAB1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning STAB1 in their description or question text
No additional research found