entity

SON

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SON: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3Connections

9Hypotheses

0Analyses

1Outgoing

2Incoming

18Experiments

0Debates

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Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Outgoing (1)

Target	Relation	Type	Str
ds-83b31ef18d49	provides_data_for	dataset	1.00

Incoming (2)

Source	Relation	Type	Str
ds-83b31ef18d49	data_in	dataset	1.00
VASOPRESSIN	expressed_in	protein	0.68

Targeting Hypotheses (9)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
NMN Supplementation Restores SIRT1/p66Shc/FOXO3 Epigenetic A	0.790	neurodegeneration	epigenetic reprogramming aging neurons
Magnetosonic-Triggered Transferrin Receptor Clustering	0.719	neurodegeneration	Blood-brain barrier transport mechanisms
HCN1-Mediated Resonance Frequency Stabilization Therapy	0.648	neurodegeneration	Selective vulnerability of entorhinal co
APOE4-Targeted Ultrasonic Lipidation Enhancement for Gamma O	0.625	Alzheimer's disease	-
SUV39H1 Restoration Represses Aberrant Transposon Expression	0.620	neurodegeneration	Investigate mechanisms of epigenetic rep

Age-Accelerated miR-155 Upregulation Primes Nigral Microglia	0.610	neuroinflammation	How do regional, age, and sex-dependent
Selectively Inhibit Maladaptive AQP4-Driven Astrocyte-Microg	0.500	neurodegeneration	How can AQP4 be effectively targeted the
Sonic hedgehog pathway compartmentalization as quantitative	0.460	neuroscience	How can subcellular compartmentalization
Multi-Clock Ensemble Discordance as a Parkinson's Disease Pr	0.377	-	Epigenetic clocks as biomarkers for Alzh

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (18)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Epigenetic clocks association with brain aging patterns in older women	exploratory	cognitive impairment and demen	0.900	0.00	human patients	proposed	N/A
iPSC-derived endothelial cell iron uptake with RLS CSF exposure	exploratory	restless legs syndrome	0.900	0.00	iPSC-derived human endothelial	proposed	N/A
PH-PS treatment in 5×FAD Alzheimer's disease mice	validation	Alzheimer's disease	0.900	0.00	5×FAD transgenic mice	proposed	N/A
AhR transcriptional regulation of NEP gene	exploratory	Alzheimer's disease	0.850	0.00	Cell culture system	proposed	N/A
Microglial SIRPα expression in human Alzheimer's disease tissue	exploratory	Alzheimer's disease	0.800	0.00	human brain tissue	proposed	N/A
Brain Connectivity-Targeted tACS Trial in Early AD	clinical	Alzheimer's Disease	0.509	0.50	human postmortem brain tissue	proposed	$520,000
s:** - Compare brain penetration in FcRn+/+ vs FcRn-/- mice with engin	falsification	Neuroinflammation	0.400	0.50	mouse	proposed	$200,000
s:** - Compare uptake with/without magnetic particles using tight junc	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$120,000
AAV Serotype Comparison for LRRK2 Knockdown in PD Gene Therapy	validation	Parkinson's Disease	0.400	0.50	mouse	proposed	$280,000
AAV Serotype Comparison for LRRK2 Knockdown in PD	validation	Parkinson's Disease	0.400	0.50	mouse	proposed	$280,000
s:** - Test whether HCN1 knockout specifically in EC layer II accelera	falsification	Alzheimer's Disease	0.400	0.50	cell_line	proposed	$80,000
tACS Connectivity Trial in Early Alzheimer's	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
Brain Connectivity-Targeted tACS Trial in Early AD	clinical	Alzheimer's Disease	0.400	0.50	mouse	proposed	$730,000
DLB Cognitive Fluctuation Mechanism Experiment	clinical	Neurodegeneration	0.400	0.50	human	proposed	$6,550,000
Levodopa Response Determinants in PSP — Biomarker-Guided Prediction St	clinical	Neurodegeneration	0.400	0.50	human	proposed	$5,460,000
Migraine Cortical Hyperexcitability and Alzheimer's Disease Risk: Long	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
Neural Oscillation Dysfunction Validation in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
Biomechanical Impact Profiles and Chronic Traumatic Encephalopathy Phe	clinical	Neurodegeneration	0.400	0.50	in_silico	proposed	$200,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
HCN channels reveal conserved and divergent physiology in supragranular pyramida [PMID:40894563]	["Radaelli C", "Schmitz M", "Liu X", "Sa	bioRxiv (Cold Spring Harbor La	2025	1
Bispecific brain-penetrant antibodies for treatment of Alzheimer's disease. [PMID:40425446]	Sehlin D, Hultqvist G, Michno W, Aguilar	J Prev Alzheimers Dis	2025	1
Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants. [PMID:39085604]	Kim ED, Wu X, Lee S, Tibbs GR, Cunningha	Nature	2024	1
Effect of ferroptosis on chronic cerebral hypoperfusion in vascular dementia. [PMID:37709116]	Fu P, Chen Y, Wu M, Bao B, Yin X, Chen Z	Exp Neurol	2023	1
The Impact of Altered HCN1 Expression on Brain Function and Its Relationship wit [PMID:37366350]	Zhao K, Li Y, Yang X, Zhou L	Curr Neuropharmacol	2023	1
HCN channels and absence seizures. [PMID:37001612]	Crunelli V, David F, Morais TP, Lorincz	Neurobiol Dis	2023	1
On Iron Metabolism and Its Regulation. [PMID:33925597]	Vogt AS, Arsiwala T, Mohsen M, Vogel M,	Int J Mol Sci	2021	1
Cardiac and neuronal HCN channelopathies. [PMID:32424620]	Rivolta I, Binda A, Masi A, DiFrancesco	Pflugers Arch	2020	1
Transferrin Receptor Is a Specific Ferroptosis Marker. [PMID:32160546]	Feng H, Schorpp K, Jin J, Yozwiak CE, Ho	Cell Rep	2020	1
Transferrin and transferrin receptors update. [PMID:29969719]	Kawabata H	Free Radic Biol Med	2019	1
HCN1 channels significantly shape retinal photoresponses. [PMID:22183410]	Tanimoto N, Brombas A, Müller F, Seelige	Adv Exp Med Biol	2012	1
HCN channels reveal conserved and divergent physiology in supragranular pyramida [PMID:41559478]	["Radaelli C", "Schmitz M", "Liu X", "Sa	Communications biology	2026	0
Comprehensive classification of HCN1 variants linked to neurodevelopmental disor [PMID:41890092]	["Castelli R", "Marini C", "Porro A", "C	bioRxiv : the preprint server	2026	0
Impact of subanesthetic ketamine delivered via AmyloLipid nanovesicle (ALN)-base [PMID:41876451]	["Levi G", "Sintov A", "Zohar J", "Todde	Translational psychiatry	2026	0
Time- and dose-dependent effects of bacterial infection on iron metabolism, infl [PMID:41619877]	Lu Y, Zhang Y, Niu C	Comp Biochem Physiol A Mol Int	2026	0
Ayanin combats against barium sulphate nanoparticles induced hepatotoxicity via [PMID:41666660]	Zhu D, Lu Y, Jamil S, Ashfaq H, Al-Emam	J Trace Elem Med Biol	2026	0
Role of iron and TfR1 in the application of high‑dose ascorbate against pancreat [PMID:41789665]	Piotrowsky A, Leischner C, Schmieder H,	Oncol Rep	2026	0
Subthreshold Kir and I [PMID:41689161]	["Moreno C", "Riquelme D", "Cornejo C",	Biological research	2026	0
Yangxin granules exert cardioprotective effects against acute myocardial infarct [PMID:41868900]	Huo G, Zhou Y, Wu Z, Sun S, Zhu G, Cheng	American journal of translatio	2026	0
Conformational dynamics study of TfR1 upon transferrin binding via NMA and MD si [PMID:41921418]	Zemmouche M, Falque G, Cadet F, Gardebie	Journal of molecular graphics	2026	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SON in their description or question text

Age-Accelerated miR-155 Upregulation Primes Nigral Microglia for Parkinson's Dis

Score: 0.610 · neuroinflammation · 2026-04-22

## Mechanistic Overview Age-Accelerated miR-155 Upregulation Primes Nigral Microglia for Parkinson's Disease Pathology s

Selectively Inhibit Maladaptive AQP4-Driven Astrocyte-Microglia Inflammatory Sig

Score: 0.500 · neurodegeneration · 2026-04-21

## Mechanistic Overview Selectively Inhibit Maladaptive AQP4-Driven Astrocyte-Microglia Inflammatory Signaling in Parkin

Sonic hedgehog pathway compartmentalization as quantitative biomarker for neuron

Score: 0.460 · neuroscience · 2026-04-26

FRET-based cAMP sensors (Epac1-camps) targeted to primary cilium (ARL13B anchor) and synaptic compartment (PSD95 anchor)

Multi-Clock Ensemble Discordance as a Parkinson's Disease Prodrome Detector — Ep

Score: 0.377 · unknown disease · 2026-04-25

Concise Statement: In Parkinson's disease, different epigenetic clock algorithms (Horvath, Hannum, PhenoAge, GrimAge) g

SON