Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SOMATOSTATIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | SOMATOSTATIN |
| GeneCards | SOMATOSTATIN |
| Human Protein Atlas | SOMATOSTATIN |
| Somatostatin-14 (SST-14) | The predominant form, 14 amino acids |
| Somatostatin-28 (SST-28) | Longer form with distinct tissue distribution |
| SSTR1 | Gi/o-coupled, inhibits adenylate cyclase |
| SSTR2 | Gi/o-coupled, primary mediator of antiproliferative effects |
| SSTR3 | Gi/o-coupled, associated with apoptosis |
| SSTR4 | Gi/o-coupled, cognitive effects |
| SSTR5 | Gi/o-coupled, growth hormone inhibition |
| Associated Diseases | BIPOLAR_DISORDER |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
SOMATOSTATIN["SOMATOSTATIN"]
BIPOLAR_DISORDER["BIPOLAR_DISORDER"]
SOMATOSTATIN -->|"associated_with"| BIPOLAR_DISORDER
style SOMATOSTATIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer'S Disease | downregulates | disease | 0.80 |
| BIPOLAR_DISORDER | associated_with | disease | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Closed-loop transcranial focused ultrasound to restore hippo | 0.767 | Alzheimer's disease | Circuit-level neural dynamics in neurode |
| Closed-loop tACS targeting EC-II somatostatin interneurons t | 0.564 | Alzheimer's disease | Circuit-level neural dynamics in neurode |
| Closed-loop transcranial focused ultrasound to restore hippo | 0.564 | Alzheimer's disease | Circuit-level neural dynamics in neurode |
| Excitatory/Inhibitory Balance Reversal via Somatostatin Inte | 0.537 | neurodegeneration | Methodology challenge: dataset 'Allen Br |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Home-Based Gamma Transcranial Alternating Current Stimulation in Patients With A [PMID:41359335] | ["Valentina Cantoni", "Elias Paolo Casul | JAMA network open | 2025 | 0 |
| Transcranial alternating current stimulation (tACS) at gamma frequency: an up-an [PMID:38926897] | De Paolis ML, Paoletti I, Zaccone C | Transl Neurodegener | 2024 | 0 |
| Inflammatory Processes in Alzheimer's Disease-Pathomechanism, Diagnosis and Trea [PMID:37047492] | Unknown | Int J Mol Sci | 2023 | 0 |
| Pathogenesis of Alzheimer's Disease. [PMID:36613544] | Unknown | Int J Mol Sci | 2022 | 0 |
| Parvalbumin neuroplasticity compensates for somatostatin impairment, maintaining [PMID:35501886] | Morrone CD, Lai AY, Bishay J, Hill ME, M | Translational neurodegeneratio | 2022 | 0 |
| Impact of 40 Hz Transcranial Alternating Current Stimulation on Cerebral Tau Bur [PMID:34958021] | M. Dhaynaut, G. Sprugnoli, D. Cappon | {'name': "Journal of Alzheimer | 2021 | 0 |
| Alzheimer's disease. [PMID:31753135] | ["Soria Lopez, Jose A", "Gonz\u00e1lez, | Handbook of clinical neurology | 2019 | 0 |
| Alzheimer's disease. [PMID:28872215] | ["Lane, C A", "Hardy, J", "Schott, J M"] | European journal of neurology | 2018 | 0 |
| Current understanding of Alzheimer's disease diagnosis and treatment. [PMID:30135715] | ["Weller, Jason", "Budson, Andrew"] | F1000Research | 2018 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning SOMATOSTATIN in their description or question text
No additional research found