protein

SMARCA2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SMARCA2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for SMARCA2 Protein (BAF155)

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🔬 Protein Info

Gene Symbol	SMARCA2
Full Name	SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 2
Aliases	BAF155
Chromosome	9p24.3
Protein Type	Enzyme
Function	encodes an ATP-dependent chromatin remodeling enzyme that serves as the catalytic subunit of the SWI/SNF (BAF) complex.
Molecular Weight	175 kDa
Amino Acids	447 aa
Exons	35
UniProt ID	[P51531](https://www.uniprot.org/uniprot/P51531)
Ensembl ID	ENSG00000080503
GeneCards	SMARCA2
Human Protein Atlas	SMARCA2
ncBAF (non-canonical BAF)	Contains BRM (but not BRG1) along with BRD9 and GLTSCR1. This complex is particularly important for neuron-specific gene regulation.
PBAF (polybromo BAF)	Requires BRG1 rather than BRM, but can incorporate BRM under certain conditions.
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SMARCA2 (BRM)

gene · 2683 words

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SMARCA2 Protein (BAF155)

protein · 1528 words

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Pathway Diagram

graph TD
    SMARCA2["SMARCA2"]
    neurodegeneration["neurodegeneration"]
    SMARCA2 -->|"implicated_in"| neurodegeneration
    style SMARCA2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning SMARCA2 in their description or question text

No additional research found