gene

SLC6A12

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLC6A12: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Betaine/GABA transporter (BGT1) gene - involved in GABAergic neurotransmission and osmotic regulation

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🧬 Gene Info

Gene Symbol	SLC6A12
Aliases	Betaine/GABA transporter (BGT1) gene
Chromosome	12p12.1
Protein Type	Gene
Function	is a member of the neurotransmitter symporter family (SLC6) and plays crucial roles in both GABAergic neurotransmission and cellular osmotic balance.
Primary Expression	various tissues, with highest expression in kidney and moderate expression in brain, where it contributes to the maintenance of inhibitory neurotransm
Molecular Weight	70 kDa
Amino Acids	614 aa
Exons	16
GeneCards	SLC6A12
Human Protein Atlas	SLC6A12
12 transmembrane domains	Hydrophobic segments that span the plasma membrane, forming the translocation pore
N-glycosylation sites	Extracellular loops that may affect trafficking and function
Conserved transport motifs	Characteristic of the SLC6 family, including the " leucine transporter" (Leut) motif
Substrate binding pocket	Specificity for GABA, betaine, and related compounds
Associated Diseases	Alzheimer's disease, Parkinson's disease, Epilepsy
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SLC6A12 Gene

gene · 2345 words

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Pathway Diagram

graph TD
    SLC6A12["SLC6A12"]
    neurodegeneration["neurodegeneration"]
    SLC6A12 -->|"implicated_in"| neurodegeneration
    style SLC6A12 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0
    style neurodegeneration fill:#455a64,stroke:#333,stroke-width:1px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning SLC6A12 in their description or question text

No additional research found