SLC39A14

protein-coding External Resolution
GeneCards NCBI PubMed

External Info (via mygene)

SymbolSLC39A14
Namesolute carrier family 39 member 14
Typeprotein-coding
Sourcemygene

Summary

This gene encodes a member of the the SLC39A family of divalent metal transporters that mediates the cellular uptake of manganese, zinc, iron, and cadmium. The encoded protein contains eight transmembrane domains, a histidine-rich motif, and a metalloprotease motif, and is expressed on the plasma membrane and the endocytic vesicle membrane. It is an important transporter of nontransferrin-bound iron and a critical regulator of manganese homeostasis. Naturally occurring mutations in this gene are

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