Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SIRT1,PGC1A,NAMPT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Metabolic Reprogramming to Reverse Senescence | 0.720 | - | Senescent cell clearance as neurodegener |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| NAD(+) metabolism, stemness, the immune response, and cancer. [PMID:33384409] | Navas LE, Carnero A | Signal Transduct Target Ther | 2021 | 1 |
| SIRT1 improves lactate homeostasis in the brain to alleviate parkinsonism via de [PMID:39128469] | Lian B, Zhang J, Yin X, Wang J, Li L et | Cell Rep Med | 2024 | 0 |
| SIRT1 improves lactate homeostasis in the brain to alleviate parkinsonism via de [PMID:39128469] | Lian B, Zhang J, Yin X, Wang J, Li L, Ju | Cell reports. Medicine | 2024 | 0 |
| Understanding the Role of Histone Deacetylase and their Inhibitors in Neurodegen [PMID:34151764] | Kumar V, Kundu S, Singh A, Singh S | Curr Neuropharmacol | 2022 | 0 |
| Understanding the Role of Histone Deacetylase and their Inhibitors in Neurodegen [PMID:34151764] | Kumar V, Kundu S, Singh A, Singh S | Current neuropharmacology | 2022 | 0 |
| Reducing acetylated tau is neuroprotective in brain injury. [PMID:33852912] | Shin MK, Vázquez-Rosa E, Koh Y, Dhar M, | Cell | 2021 | 0 |
| Reducing acetylated tau is neuroprotective in brain injury. [PMID:33852912] | ["Shin M", "V\u00e1zquez-Rosa E", "Koh Y | Cell | 2021 | 0 |
| Role of advanced glycation end products in cellular signaling. [PMID:24624331] | Ott C, Jacobs K, Haucke E, Navarrete San | Redox Biol | 2014 | 0 |
| Role of advanced glycation end products in cellular signaling. [PMID:24624331] | Ott C, Jacobs K, Haucke E, Navarrete San | Redox biology | 2014 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning SIRT1,PGC1A,NAMPT in their description or question text
No additional research found