gene

SHRM3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SHRM3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

SHRM3 (Shroom Family Member 3) is an actin-binding protein involved in cellular morphogenesis, tissue development, and cytoskeletal dynamics. It plays critical roles in apical constriction, neural tube formation, and synaptic plasticity, with implications for neurodegenerative diseases.

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🧬 Gene Info

Gene Symbol	SHRM3
Full Name	Shroom Family Member 3
Chromosome	19q13.42
Function	is an actin-binding protein that plays critical roles in cellular morphogenesis and tissue development [simic2018](https://pubmed.
Primary Expression	both developing and adult tissues, with particularly high expression in the nervous system and kidney [hatano2020](https://pubmed
Subcellular Localization	2. Central region: Contains binding sites for actin and myosin
Molecular Weight	210 kDa
Amino Acids	1934 aa
Ensembl ID	ENSG00000104892
GeneCards	SHRM3
Human Protein Atlas	SHRM3
Neural plate bending	Initiates folding of the neural plate
Neural fold elevation	Promotes elevation of neural folds
Fusion of folds	Facilitates closure at the midline
Spina bifida prevention	Proper SHRM3 function prevents neural tube defects
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SHRM3 — Shroom Family Member 3

gene · 1313 words

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Pathway Diagram

graph TD
    SHRM3["SHRM3"]
    neurodegeneration["neurodegeneration"]
    SHRM3 -->|"implicated in"| neurodegeneration
    Neurodegenerative_Diseases{"Neurodegenerative Diseases"}
    SHRM3 -->|"implicated in"| Neurodegenerative_Diseases
    Synaptic_Plasticity(["Synaptic Plasticity"])
    SHRM3 -->|"regulates"| Synaptic_Plasticity
    style SHRM3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
    style Neurodegenerative_Diseases fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350
    style Synaptic_Plasticity fill:#2a2a1a,stroke:#ffd54f,stroke-width:1px,color:#ffd54f

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SHRM3 in their description or question text

No additional research found