gene

SHANK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SHANK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2Connections

0Hypotheses

0Analyses

1Outgoing

1Incoming

0Experiments

0Debates

Summary

Page for SHANK1 — SH3 and Multiple Ankyrin Repeat Domains 3

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🧬 Gene Info

Gene Symbol	SHANK1
Full Name	SH3 and Multiple Ankyrin Repeat Domains 3
Aliases	Postsynaptic Scaffold
Protein Type	Protein
Function	Scaffold Assembly: Shank1 connects membrane proteins to the actin cytoskeleton
Subcellular Localization	dendrites, where local translation occurs in response to synaptic activity. The protein is enriched in the postsynaptic
Molecular Weight	230 kDa
Amino Acids	2160 aa
UniProt ID	Q9Y2X2
GeneCards	SHANK1
Human Protein Atlas	SHANK1
Organizes PSD	Forms the core of the postsynaptic density
Links receptors to cytoskeleton	Connects AMPA/NMDA receptors to actin
Associated Diseases	neurodegeneration
KG Connections	2 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: SHANK1 — AlphaFold Q9Y2X2 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SHANK1 — SH3 and Multiple Ankyrin Repeat Domains 3

gene · 692 words

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SHANK1 — Shank1 Protein (Postsynaptic Scaffold)

protein · 669 words

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Pathway Diagram

graph TD
    SHANK1["SHANK1"]
    Autism["Autism"]
    AND["AND"]
    SHANK3["SHANK3"]
    neurodegeneration["neurodegeneration"]

    SHANK1 -->|"activates"| Autism
    SHANK1 -->|"expressed in"| AND
    SHANK3 -->|"expressed in"| SHANK1
    SHANK1 -->|"implicated in"| neurodegeneration

    style SHANK1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
    style Autism fill:#3e1a1a,stroke:#ef5350,stroke-width:2px,color:#fff
    style AND fill:#1a237e,stroke:#ce93d8,stroke-width:2px,color:#fff
    style SHANK3 fill:#1a237e,stroke:#ce93d8,stroke-width:2px,color:#fff
    style neurodegeneration fill:#1a1a2e,stroke:#888,stroke-width:2px,color:#fff

Outgoing (1)

Target	Relation	Type	Str
Autism	activates	disease	0.65

Incoming (1)

Source	Relation	Type	Str
SHANK3	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SHANK1 in their description or question text

No additional research found