gene

SGK2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SGK2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Hypotheses

0Analyses

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0Experiments

0Debates

Summary

SGK2 encodes a serine/threonine protein kinase regulated by glucocorticoids and cellular stress. Key player in PI3K/AKT signaling, ion channel regulation, neuronal survival, and synaptic plasticity. Relevant to Alzheimer's and Parkinson's disease.

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🧬 Gene Info

Gene Symbol	SGK2
Full Name	Serum/Glucocorticoid Regulated Kinase 2
Chromosome	19q13.31
Protein Type	Kinase
Function	encodes a member of the serum/glucocorticoid regulated kinase (SGK) family of serine/threonine protein kinases.
Amino Acids	431 aa
Exons	14
Pathways	PI3K signaling, PI3K
UniProt ID	Q9Y296
NCBI Gene ID	10156
Ensembl ID	ENSG00000109991
OMIM	602505
GeneCards	SGK2
Human Protein Atlas	SGK2
1990s	SGK family identified
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SGK2 — AlphaFold Q9Y296 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SGK2 Gene

gene · 1827 words

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Pathway Diagram

graph TD
    SGK2["SGK2"]
    neurodegeneration["neurodegeneration"]
    SGK2 -->|"implicated in"| neurodegeneration
    Alzheimer_S{"Alzheimer'S"}
    SGK2 -->|"implicated in"| Alzheimer_S
    Parkinson_S_Disease{"Parkinson'S Disease"}
    SGK2 -->|"implicated in"| Parkinson_S_Disease
    Neuronal_Survival(["Neuronal Survival"])
    SGK2 -->|"promotes"| Neuronal_Survival
    Synaptic_Plasticity(["Synaptic Plasticity"])
    SGK2 -->|"regulates"| Synaptic_Plasticity
    AKT["AKT"]
    SGK2 ---|"interacts"| AKT
    PI3K["PI3K"]
    SGK2 ---|"interacts"| PI3K
    style SGK2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
    style Parkinson_S_Disease fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350
    style Alzheimer_S fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350
    style Synaptic_Plasticity fill:#2a2a1a,stroke:#ffd54f,stroke-width:1px,color:#ffd54f
    style Neuronal_Survival fill:#2a2a1a,stroke:#ffd54f,stroke-width:1px,color:#ffd54f

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SGK2 in their description or question text

No additional research found