gene

SDHAF2

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about SDHAF2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

5Connections

0Hypotheses

0Analyses

5Outgoing

0Incoming

0Experiments

0Debates

Summary

Page for SDHAF2 Gene

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🧬 Gene Info

Gene Symbol	SDHAF2
Full Name	Succinate Dehydrogenase Assembly Factor 2
Chromosome	11q12.1
Function	is a critical mitochondrial protein involved in the proper assembly and function of succinate dehydrogenase (SDH), also known as Complex II of the electron transport chain.
Amino Acids	116 aa
UniProt ID	Q9H3K2
NCBI Gene ID	63920
Ensembl ID	ENSG00000167117
OMIM	613018
GeneCards	SDHAF2
Human Protein Atlas	SDHAF2
Associated Diseases	Paraganglioma, Pheochromocytoma, Pituitary Neuroendocrine Tumors
KG Connections	5 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SDHAF2 — AlphaFold Q9H3K2 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SDHAF2 - Succinate Dehydrogenase Assembly Factor 2

gene · 1392 words

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Pathway Diagram

flowchart TD
    SDHAF2(["SDHAF2"])
    Paraganglioma["Paraganglioma"]
    Pheochromocytoma["Pheochromocytoma"]
    Succinate_Dehydrogenase["Succinate Dehydrogenase"]
    Pituitary_Neuroendocrine_Tumors["Pituitary Neuroendocrine Tumors"]
    Tumorigenesis("Tumorigenesis")
    neurodegeneration["neurodegeneration"]

    SDHAF2 -->|"causes"| Paraganglioma
    SDHAF2 -->|"causes"| Pheochromocytoma
    SDHAF2 -->|"participates in"| Succinate_Dehydrogenase
    SDHAF2 -->|"associated with"| Pituitary_Neuroendocrine_Tumors
    SDHAF2 -->|"contributes to"| Tumorigenesis
    SDHAF2 -->|"implicated in"| neurodegeneration

    style SDHAF2 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (5)

Target	Relation	Type	Str
Paraganglioma	causes	disease	0.80
Pheochromocytoma	causes	disease	0.80
Succinate Dehydrogenase	participates_in	enzyme	0.80
Pituitary Neuroendocrine Tumors	associated_with	disease	0.70
Tumorigenesis	contributes_to	biological_process	0.60

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SDHAF2 in their description or question text

No additional research found