protein

SACSPROTEIN

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about SACSPROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Sacsin is a 4,579-amino acid multidomain protein that integrates chaperone activity with mitochondrial regulation and cytoskeletal remodeling<sup>[1]</sup>.

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🔬 Protein Info

Gene Symbol	SACSPROTEIN
Protein Type	Chaperone
Function	is a 4,579-amino acid multidomain protein that integrates chaperone activity with mitochondrial regulation and cytoskeletal remodeling<sup>[1]</sup>.
Subcellular Localization	** \| Cytoplasm, mitochondria-associated \|
Molecular Weight	520 kDa
Amino Acids	579 aa
GeneCards	SACSPROTEIN
Human Protein Atlas	SACSPROTEIN
Three Sacsin Repeating Regions (SRR1-3)	Hsp90-like ATPase domains; each ~400 aa with ATP binding and hydrolysis
XPCB domain	Xeroderma pigmentosum group C binding domain; involved in DNA damage response
DnaJ domain	J-domain that recruits and activates Hsp70 chaperones
Fission promotion	Loss of sacsin causes hyperfused, elongated mitochondrial networks
Mitophagy	Required for efficient PINK1/Parkin-mediated mitophagy
Bioenergetics	Sacsin-deficient cells show reduced mitochondrial membrane potential and ATP production
Calcium buffering	Mitochondrial elongation impairs Ca²⁺ uptake dynamics
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Sacsin (SACS Protein)

protein · 934 words

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Pathway Diagram

graph TD
    SACSPROTEIN["SACSPROTEIN"]
    neurodegeneration["neurodegeneration"]
    SACSPROTEIN -->|"implicated_in"| neurodegeneration
    style SACSPROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

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Mentioning Analyses (0)

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Experiments (0)

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Related Papers (0)

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Related Research

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