entity

R_loop_resolution

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about R_loop_resolution: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1Connections

1Hypotheses

1Analyses

0Outgoing

1Incoming

10Experiments

1Debates

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Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (1)

Source	Relation	Type	Str
SETX	activates	protein	0.70

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
R-Loop Resolution Enhancement Therapy	0.680	neurodegeneration	RNA binding protein dysregulation across

Mentioning Analyses (1)

Scientific analyses that reference this entity

RNA binding protein dysregulation across ALS FTD and AD

neurodegeneration | 2026-04-01 | 0 hypotheses

Experiments (10)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
s:** - Temporal analysis showing mitochondrial defects precede other p	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$80,000
Proposed experiment from debate on TDP-43 undergoes liquid-liquid phas	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$80,000
s:** - Single-cell RNA-seq to measure editing efficiency across differ	falsification	ALS	0.400	0.50	cell_line	proposed	$150,000
ALS Progression Rate Heterogeneity — mechanism and biomarker predictor	clinical	ALS	0.400	0.50	human	proposed	$6,550,000
ALS Regional Onset and Spread: Network-Level Staging Model	clinical	ALS	0.400	0.50	human	proposed	$7,500,000
Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk Cohorts	clinical	ALS	0.400	0.50	human	proposed	$6,550,000
DNA Damage Repair Deficiency Validation Study in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	completed	$7,500,000
Environmental Exposure Causal Attribution in ALS — Experiment Design	validation	ALS	0.400	0.50	human	proposed	$3,000,000
Frontal and Temporal Lobe Selective Vulnerability in FTD — Mechanisms	validation	Neurodegeneration	0.400	0.50	human	proposed	$3,000,000
FXTAS Phenotypic Penetrance: Why Only 40% of FMR1 Premutation Carriers	validation	ALS	0.400	0.50	human	proposed	$3,000,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Allele-specific silencing of a dominant SETX mutation in familial amyotrophic la [PMID:40200577]	Winkelsas A, Apfel A, Johnson B, Harmiso	HGG Adv	2025	1
SETX (senataxin), the helicase mutated in AOA2 and ALS4, functions in autophagy [PMID:32686621]	Richard P, Feng S, Tsai YL, Li W, Rinche	Autophagy	2021	1
Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent D [PMID:31533039]	Cristini A, Ricci G, Britton S, Salimben	Cell Rep	2019	1
Molecular characterization of recessively inherited ataxic and neuropathic disor [PMID:41606223]	["Aslam F", "Wajid M", "Butt A", "Wohler	Scientific reports	2026	0
Deciphering ALS-linked genetic variants in indian patients using targeted and ex [PMID:41137727]	["Reza S", "Handique J", "Sharma P", "Ma	Amyotrophic lateral sclerosis	2026	0
Genetic commonalities between rare subtypes of ALS and CMT: insights into molecu [PMID:41621017]	Aynaashe A, Kursula P	Amino Acids	2026	0
Genetic commonalities between rare subtypes of ALS and CMT: insights into molecu [PMID:41621017]	Aynaashe A, Kursula P	Amino acids	2026	0
N(6)-methyladenosine modification of RNA is regulated by senataxin and E6 to con [PMID:41518615]	["Templeton C", "Laimins L"]	Cell reports	2026	0
The SMC5/SMC6 complex is critical for resolving R-loop-induced transcription-rep [PMID:41533569]	Wu T, Li Y, Zhao Y, Bournique E, Ortega	Nucleic acids research	2026	0
Resolution of R-loops and transcription-replication conflicts by SETX-BRCA1-BARD [PMID:41917467]	Dutta A, Ji JH, Syed S, Fang Q, Mukhopad	Nature structural & molecular	2026	0
Ataxia and oculomotor apraxia caused by a large-scale deletion in the senataxin [PMID:40830689]	["Rusecka J", "Kierdaszuk B", "St\u0119p	Journal of applied genetics	2025	0
Unraveling the genetic landscape of ALS in Greece: identification of known and n [PMID:41196070]	["Kartanou C", "Kontogeorgiou Z", "Loupi	Amyotrophic lateral sclerosis	2025	0
Break-induced replication is activated to repair R-loop-associated double-strand [PMID:40475435]	["Wu T", "Li Y", "Shi L", "Wu X"]	bioRxiv : the preprint server	2025	0
A role for human senataxin in contending with pausing and backtracking during tr [PMID:41232527]	Han Z, Fu S, Johansen JV, Lopez Martinez	Molecular cell	2025	0
Break-induced replication is activated to repair R-loop-associated double-strand [PMID:41037402]	Wu T, Li Y, Zhao Y, Shah SB, Shi LZ, Wu	Cell reports	2025	0
Unveiling ten novel SETX mutations: implications for ALS pathogenesis and clinic [PMID:40338003]	["Chen X", "Chen X", "Lin X", "Zhou W",	Somatosensory & motor research	2025	0
ZPR1 Is Dispensable for HPV R-Loop Resolution but Regulates Host R-Loop Dynamics [PMID:41305523]	Moffitt R, Brooks S, Androphy EJ, DeSmet	Viruses	2025	0
Senataxin: A key actor in RNA metabolism, genome integrity and neurodegeneration [PMID:37558082]	["Giannini M", "Porrua O"]	Biochimie	2024	0
Role of senataxin in R-loop-mediated neurodegeneration. [PMID:39070547]	Kannan A, Gangadharan Leela S, Branzei D	Brain communications	2024	0
Helicases in R-loop Formation and Resolution. [PMID:37778731]	Yang S, Winstone L, Mondal S, Wu Y	The Journal of biological chem	2023	0

Debates (1)

Multi-agent debates referencing this entity

What are the mechanisms underlying rna binding protein dysregulation across als

closed · Rounds: 4 · Score: 0.92 · 2026-04-01

Related Research

Hypotheses and analyses mentioning R_loop_resolution in their description or question text

No additional research found